BRD-K51816706_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

287 genes differentially expressed following the BRD-K51816706_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ABLIM1 actin binding LIM protein 1
ACVR1 activin A receptor, type I
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALB albumin
ANXA1 annexin A1
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCL20 chemokine (C-C motif) ligand 20
CD163 CD163 molecule
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
COMP cartilage oligomeric matrix protein
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DARS aspartyl-tRNA synthetase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EFNA1 ephrin-A1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5 eukaryotic translation initiation factor 5
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM129A family with sequence similarity 129, member A
FN1 fibronectin 1
FNDC3B fibronectin type III domain containing 3B
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
FZD5 frizzled class receptor 5
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GPX2 glutathione peroxidase 2
GRB10 growth factor receptor-bound protein 10
HIST1H2AC histone cluster 1, H2ac
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IARS isoleucyl-tRNA synthetase
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL32 interleukin 32
IRF1 interferon regulatory factor 1
ISG20 interferon stimulated exonuclease gene 20kDa
ISLR immunoglobulin superfamily containing leucine-rich repeat
JUNB jun B proto-oncogene
KDM7A lysine (K)-specific demethylase 7A
KIZ kizuna centrosomal protein
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KRT17 keratin 17, type I
KYNU kynureninase
LAMB3 laminin, beta 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP1B microtubule-associated protein 1B
MTSS1 metastasis suppressor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUPR1 nuclear protein, transcriptional regulator, 1
PEG3 paternally expressed 3
PELI1 pellino E3 ubiquitin protein ligase 1
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIR pirin (iron-binding nuclear protein)
PNRC1 proline-rich nuclear receptor coactivator 1
PPAP2B phosphatidic acid phosphatase type 2B
PRNP prion protein
PSAT1 phosphoserine aminotransferase 1
RAP1GAP RAP1 GTPase activating protein
RBMS1 RNA binding motif, single stranded interacting protein 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RIOK3 RIO kinase 3
RIPK2 receptor-interacting serine-threonine kinase 2
RND3 Rho family GTPase 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRAGC Ras-related GTP binding C
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SCRG1 stimulator of chondrogenesis 1
SDC4 syndecan 4
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERTAD2 SERTA domain containing 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SMOX spermine oxidase
SNAI2 snail family zinc finger 2
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPRED2 sprouty-related, EVH1 domain containing 2
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
TES testin LIM domain protein
TF transferrin
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKT transketolase
TM4SF1 transmembrane 4 L six family member 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TP53I3 tumor protein p53 inducible protein 3
TRIB1 tribbles pseudokinase 1
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TUBB2B tubulin, beta 2B class IIb
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UPP1 uridine phosphorylase 1
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WDR45 WD repeat domain 45
XIST X inactive specific transcript (non-protein coding)
YARS tyrosyl-tRNA synthetase
ZBTB20 zinc finger and BTB domain containing 20
ZFAND5 zinc finger, AN1-type domain 5
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AGR2 anterior gradient 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
AP2S1 adaptor-related protein complex 2, sigma 1 subunit
ARG1 arginase 1
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARMT1 acidic residue methyltransferase 1
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
ATPIF1 ATPase inhibitory factor 1
B3GNT1
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
BIRC5 baculoviral IAP repeat containing 5
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CENPA centromere protein A
CENPM centromere protein M
CENPN centromere protein N
CETN2 centrin, EF-hand protein, 2
CMC2 C-x(9)-C motif containing 2
CRISP3 cysteine-rich secretory protein 3
CXCL12 chemokine (C-X-C motif) ligand 12
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F8 E2F transcription factor 8
EFNB2 ephrin-B2
EMP2 epithelial membrane protein 2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EVL Enah/Vasp-like
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FHL1 four and a half LIM domains 1
FOXM1 forkhead box M1
GATA3 GATA binding protein 3
GHR growth hormone receptor
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GMNN geminin, DNA replication inhibitor
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HEXIM1 hexamethylene bis-acetamide inducible 1
HOXC6 homeobox C6
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
ICMT isoprenylcysteine carboxyl methyltransferase
IGFBP5 insulin-like growth factor binding protein 5
KANK2 KN motif and ankyrin repeat domains 2
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRGN neurogranin (protein kinase C substrate, RC3)
NT5DC2 5'-nucleotidase domain containing 2
NUSAP1 nucleolar and spindle associated protein 1
PCNA proliferating cell nuclear antigen
PGRMC1 progesterone receptor membrane component 1
PLK1 polo-like kinase 1
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPIH peptidylprolyl isomerase H (cyclophilin H)
PRC1 protein regulator of cytokinesis 1
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM2 ribonucleotide reductase M2
RUSC1 RUN and SH3 domain containing 1
SEPW1 selenoprotein W, 1
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SPDEF SAM pointed domain containing ETS transcription factor
STMN1 stathmin 1
STRA13 stimulated by retinoic acid 13
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
TK1 thymidine kinase 1, soluble
TM7SF2 transmembrane 7 superfamily member 2
TMEM106C transmembrane protein 106C
TMEM14A transmembrane protein 14A
TMEM164 transmembrane protein 164
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAPPC4 trafficking protein particle complex 4
TRIP13 thyroid hormone receptor interactor 13
TSPAN13 tetraspanin 13
TSPYL5 TSPY-like 5
TUBA1A tubulin, alpha 1a
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X
ZWINT ZW10 interacting kinetochore protein