BRD-K51816706_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-K51816706_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOLD1 apolipoprotein L domain containing 1
AQP3 aquaporin 3 (Gill blood group)
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
C10ORF10 chromosome 10 open reading frame 10
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CCNE2 cyclin E2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFLAR CASP8 and FADD-like apoptosis regulator
COL6A2 collagen, type VI, alpha 2
CTGF connective tissue growth factor
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DFNA5 deafness, autosomal dominant 5
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
FABP7 fatty acid binding protein 7, brain
FAM107A family with sequence similarity 107, member A
FAM129A family with sequence similarity 129, member A
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
G6PD glucose-6-phosphate dehydrogenase
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GEM GTP binding protein overexpressed in skeletal muscle
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IGF1R insulin-like growth factor 1 receptor
JAG1 jagged 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KDM6B lysine (K)-specific demethylase 6B
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KTN1 kinectin 1 (kinesin receptor)
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NCALD neurocalcin delta
NFE2L2 nuclear factor, erythroid 2-like 2
NFIB nuclear factor I/B
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RGS1 regulator of G-protein signaling 1
RHOB ras homolog family member B
RRAGD Ras-related GTP binding D
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERTAD2 SERTA domain containing 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STC1 stanniocalcin 1
STC2 stanniocalcin 2
TACSTD2 tumor-associated calcium signal transducer 2
TNPO1 transportin 1
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VWF von Willebrand factor
ZBTB16 zinc finger and BTB domain containing 16
ZBTB18 zinc finger and BTB domain containing 18
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZYX zyxin

decreased expression

Symbol Name
AFP alpha-fetoprotein
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA4 annexin A4
AUTS2 autism susceptibility candidate 2
C6ORF62 chromosome 6 open reading frame 62
CD36 CD36 molecule (thrombospondin receptor)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CGA glycoprotein hormones, alpha polypeptide
CRIP1 cysteine-rich protein 1 (intestinal)
CTSV cathepsin V
CXCL14 chemokine (C-X-C motif) ligand 14
DMD dystrophin
EIF4B eukaryotic translation initiation factor 4B
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
FLRT3 fibronectin leucine rich transmembrane protein 3
GJA1 gap junction protein, alpha 1, 43kDa
IFRD2 interferon-related developmental regulator 2
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
MAT2A methionine adenosyltransferase II, alpha
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDZD2 PDZ domain containing 2
PRKCB protein kinase C, beta
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
S100A8 S100 calcium binding protein A8
SLC39A8 solute carrier family 39 (zinc transporter), member 8
TPBG trophoblast glycoprotein