BRD-K51791390_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

134 genes differentially expressed following the BRD-K51791390_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADGRF5 adhesion G protein-coupled receptor F5
AKAP12 A kinase (PRKA) anchor protein 12
AKR1C3 aldo-keto reductase family 1, member C3
ALDOC aldolase C, fructose-bisphosphate
ATF3 activating transcription factor 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
CHGB chromogranin B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLIC5 chloride intracellular channel 5
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL6A1 collagen, type VI, alpha 1
CP ceruloplasmin (ferroxidase)
CTGF connective tissue growth factor
CTSC cathepsin C
CXCL14 chemokine (C-X-C motif) ligand 14
CXCR4 chemokine (C-X-C motif) receptor 4
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DPYSL3 dihydropyrimidinase-like 3
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EPAS1 endothelial PAS domain protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EZR ezrin
F13A1 coagulation factor XIII, A1 polypeptide
FABP4 fatty acid binding protein 4, adipocyte
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FN1 fibronectin 1
FRZB frizzled-related protein
G0S2 G0/G1 switch 2
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMOX1 heme oxygenase 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IGFBP6 insulin-like growth factor binding protein 6
IGHM immunoglobulin heavy constant mu
IL32 interleukin 32
KRT7 keratin 7, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LIMCH1 LIM and calponin homology domains 1
LMO3 LIM domain only 3 (rhombotin-like 2)
MAN1A1 mannosidase, alpha, class 1A, member 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
MTSS1 metastasis suppressor 1
NDRG1 N-myc downstream regulated 1
NPTX2 neuronal pentraxin II
NRCAM neuronal cell adhesion molecule
OLFM4 olfactomedin 4
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG10 paternally expressed 10
PERP PERP, TP53 apoptosis effector
PLAU plasminogen activator, urokinase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLIN2 perilipin 2
PLXND1 plexin D1
PTX3 pentraxin 3, long
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RBP4 retinol binding protein 4, plasma
RGS16 regulator of G-protein signaling 16
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SFRP4 secreted frizzled-related protein 4
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SNAI2 snail family zinc finger 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SST somatostatin
STMN2 stathmin 2
SYNPO synaptopodin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS2 thrombospondin 2
TMSB15A thymosin beta 15a
TPP1 tripeptidyl peptidase I
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIM2 tripartite motif containing 2
TSKU tsukushi, small leucine rich proteoglycan
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VSIG4 V-set and immunoglobulin domain containing 4
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ATF5 activating transcription factor 5
BIRC5 baculoviral IAP repeat containing 5
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CLU clusterin
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DMD dystrophin
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EXOSC4 exosome component 4
GPER1 G protein-coupled estrogen receptor 1
GTPBP8 GTP-binding protein 8 (putative)
ICAM3 intercellular adhesion molecule 3
IL1RN interleukin 1 receptor antagonist
LIG1 ligase I, DNA, ATP-dependent
LUC7L3 LUC7-like 3 (S. cerevisiae)
MYCBP MYC binding protein
NKTR natural killer cell triggering receptor
PEBP1 phosphatidylethanolamine binding protein 1
PPIF peptidylprolyl isomerase F
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SEPW1 selenoprotein W, 1
SFRP1 secreted frizzled-related protein 1
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPOP speckle-type POZ protein
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TESC tescalcin
TMED3 transmembrane emp24 protein transport domain containing 3
TMEM47 transmembrane protein 47
TOR1AIP1 torsin A interacting protein 1
TSPYL5 TSPY-like 5
UGCG UDP-glucose ceramide glucosyltransferase