BRD-K51781482_IKK-3 Inhibitor IX_SW620_6.0_h_6.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

96 genes differentially expressed following the BRD-K51781482_IKK-3 Inhibitor IX_SW620_6.0_h_6.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AMIGO2 adhesion molecule with Ig-like domain 2
BPHL biphenyl hydrolase-like (serine hydrolase)
CA2 carbonic anhydrase II
CALR calreticulin
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CAST calpastatin
CD58 CD58 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHN1 chimerin 1
CSTA cystatin A (stefin A)
CXADR coxsackie virus and adenovirus receptor
CYCS cytochrome c, somatic
DCLK1 doublecortin-like kinase 1
DLD dihydrolipoamide dehydrogenase
DLK1 delta-like 1 homolog (Drosophila)
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DST dystonin
ENO1 enolase 1, (alpha)
F11R F11 receptor
FSCN1 fascin actin-bundling protein 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GRB7 growth factor receptor-bound protein 7
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
IL17RB interleukin 17 receptor B
JAG1 jagged 1
KLF11 Kruppel-like factor 11
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
KRT7 keratin 7, type II
KRT81 keratin 81, type II
KYNU kynureninase
LMO3 LIM domain only 3 (rhombotin-like 2)
MTSS1 metastasis suppressor 1
MYBPC1 myosin binding protein C, slow type
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFM1 olfactomedin 1
PDE4B phosphodiesterase 4B, cAMP-specific
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PKM pyruvate kinase, muscle
PODXL podocalyxin-like
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSD3 pleckstrin and Sec7 domain containing 3
PTN pleiotrophin
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SDC1 syndecan 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SIK1 salt-inducible kinase 1
TRIM2 tripartite motif containing 2
TUBB2A tubulin, beta 2A class IIa
VNN1 vanin 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

decreased expression

Symbol Name
AGR2 anterior gradient 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ASMTL acetylserotonin O-methyltransferase-like
AXIN1 axin 1
BEX1 brain expressed, X-linked 1
CD99 CD99 molecule
CES1 carboxylesterase 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTL1 cytokine-like 1
DCXR dicarbonyl/L-xylulose reductase
DDHD2 DDHD domain containing 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FKBP1B FK506 binding protein 1B, 12.6 kDa
FZD2 frizzled class receptor 2
GPX3 glutathione peroxidase 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1R2 interleukin 1 receptor, type II
INHBA inhibin, beta A
KDM5D lysine (K)-specific demethylase 5D
KLK11 kallikrein-related peptidase 11
LAMP5 lysosomal-associated membrane protein family, member 5
LTBP3 latent transforming growth factor beta binding protein 3
MXRA7 matrix-remodelling associated 7
MYB v-myb avian myeloblastosis viral oncogene homolog
NEFH neurofilament, heavy polypeptide
NKG7 natural killer cell granule protein 7
NME4 NME/NM23 nucleoside diphosphate kinase 4
OLFM4 olfactomedin 4
PAAF1 proteasomal ATPase-associated factor 1
PENK proenkephalin
RELN reelin
SIDT2 SID1 transmembrane family, member 2
SLC46A3 solute carrier family 46, member 3
TBL1X transducin (beta)-like 1X-linked
ZNF586 zinc finger protein 586