BRD-K51683034_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

71 genes differentially expressed following the BRD-K51683034_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ASNS asparagine synthetase (glutamine-hydrolyzing)
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BEX1 brain expressed, X-linked 1
CLIC4 chloride intracellular channel 4
COPA coatomer protein complex, subunit alpha
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
EZR ezrin
FASN fatty acid synthase
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
G6PD glucose-6-phosphate dehydrogenase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-B major histocompatibility complex, class I, B
HMOX1 heme oxygenase 1
HOOK2 hook microtubule-tethering protein 2
IER3 immediate early response 3
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
MAP7 microtubule-associated protein 7
MCL1 myeloid cell leukemia 1
MFSD10 major facilitator superfamily domain containing 10
NREP neuronal regeneration related protein
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDLIM5 PDZ and LIM domain 5
RCAN1 regulator of calcineurin 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TKT transketolase
TPP1 tripeptidyl peptidase I
TRIB3 tribbles pseudokinase 3
VEGFA vascular endothelial growth factor A
VIM vimentin
VNN1 vanin 1
WARS tryptophanyl-tRNA synthetase

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ADGRG2 adhesion G protein-coupled receptor G2
C1ORF116 chromosome 1 open reading frame 116
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C3 complement component 3
C7 complement component 7
CD163 CD163 molecule
CD9 CD9 molecule
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FBLN1 fibulin 1
GMPR guanosine monophosphate reductase
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
IFI6 interferon, alpha-inducible protein 6
ISG15 ISG15 ubiquitin-like modifier
KDM5D lysine (K)-specific demethylase 5D
LEF1 lymphoid enhancer-binding factor 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAN1C1 mannosidase, alpha, class 1C, member 1
MSH6 mutS homolog 6
PCP4 Purkinje cell protein 4
PLLP plasmolipin
PTCH1 patched 1
RABGAP1L RAB GTPase activating protein 1-like
REEP1 receptor accessory protein 1
RPS11 ribosomal protein S11
RRM2 ribonucleotide reductase M2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERINC5 serine incorporator 5
TFPI2 tissue factor pathway inhibitor 2
VAMP8 vesicle-associated membrane protein 8