BRD-K51662849_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

66 genes differentially expressed following the BRD-K51662849_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
CAPN7 calpain 7
CCDC92 coiled-coil domain containing 92
CD58 CD58 molecule
CPB1 carboxypeptidase B1 (tissue)
DUSP1 dual specificity phosphatase 1
G0S2 G0/G1 switch 2
HBD hemoglobin, delta
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KDM3A lysine (K)-specific demethylase 3A
LDHB lactate dehydrogenase B
LOX lysyl oxidase
LTF lactotransferrin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MTCL1 microtubule crosslinking factor 1
MYO6 myosin VI
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOX4 NADPH oxidase 4
NRN1 neuritin 1
NUP98 nucleoporin 98kDa
PDLIM5 PDZ and LIM domain 5
PERP PERP, TP53 apoptosis effector
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRAME preferentially expressed antigen in melanoma
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52L2 tumor protein D52-like 2
TRBC1 T cell receptor beta constant 1
TXNIP thioredoxin interacting protein
VAV3 vav 3 guanine nucleotide exchange factor
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ATF3 activating transcription factor 3
CCND1 cyclin D1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHRS7 dehydrogenase/reductase (SDR family) member 7
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5 eukaryotic translation initiation factor 5
FCGBP Fc fragment of IgG binding protein
FLNA filamin A, alpha
GPM6B glycoprotein M6B
IGF1 insulin-like growth factor 1 (somatomedin C)
IGHD immunoglobulin heavy constant delta
ISLR immunoglobulin superfamily containing leucine-rich repeat
LDLR low density lipoprotein receptor
LPCAT1 lysophosphatidylcholine acyltransferase 1
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
PAPD7 PAP associated domain containing 7
PEG10 paternally expressed 10
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
RNF167 ring finger protein 167
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SNX7 sorting nexin 7
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STAB1 stabilin 1
SYBU syntabulin (syntaxin-interacting)
TPBG trophoblast glycoprotein