BRD-K51608872_N,N-dimethyl-6-({[1-(1-naphthyl)-1H-tetrazol-5-yl]thio}methyl)-1,3,5-triazine-2,4-diamine_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-K51608872_N,N-dimethyl-6-({[1-(1-naphthyl)-1H-tetrazol-5-yl]thio}methyl)-1,3,5-triazine-2,4-diamine_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
ATF3 activating transcription factor 3
BHLHE41 basic helix-loop-helix family, member e41
BTG2 BTG family, member 2
CD200 CD200 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CNN3 calponin 3, acidic
CTGF connective tissue growth factor
CXADR coxsackie virus and adenovirus receptor
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
DOK5 docking protein 5
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
EGR1 early growth response 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EPYC epiphycan
FABP1 fatty acid binding protein 1, liver
FBXL12 F-box and leucine-rich repeat protein 12
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GIPC2 GIPC PDZ domain containing family, member 2
H3F3B H3 histone, family 3B (H3.3B)
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
IFI6 interferon, alpha-inducible protein 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF6 Kruppel-like factor 6
KRT19 keratin 19, type I
LOC100505650 uncharacterized LOC100505650
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MDK midkine (neurite growth-promoting factor 2)
MTSS1 metastasis suppressor 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRUNE2 prune homolog 2 (Drosophila)
RBP1 retinol binding protein 1, cellular
RCAN1 regulator of calcineurin 1
RGCC regulator of cell cycle
RHOB ras homolog family member B
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SESN1 sestrin 1
SFRP4 secreted frizzled-related protein 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX17 SRY (sex determining region Y)-box 17
SRGN serglycin
SRSF6 serine/arginine-rich splicing factor 6
SYBU syntabulin (syntaxin-interacting)
SYT1 synaptotagmin I
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CCND3 cyclin D3
COL4A2 collagen, type IV, alpha 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EXOSC4 exosome component 4
G0S2 G0/G1 switch 2
GNAS GNAS complex locus
GPI glucose-6-phosphate isomerase
HACD3 3-hydroxyacyl-CoA dehydratase 3
HMGA2 high mobility group AT-hook 2
JMJD6 jumonji domain containing 6
MCM6 minichromosome maintenance complex component 6
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MT1X metallothionein 1X
NKX3-1 NK3 homeobox 1
PCOLCE2 procollagen C-endopeptidase enhancer 2
PFKP phosphofructokinase, platelet
PHLDA2 pleckstrin homology-like domain, family A, member 2
S100A2 S100 calcium binding protein A2
SEC16A SEC16 homolog A (S. cerevisiae)
SFRP1 secreted frizzled-related protein 1
SOX11 SRY (sex determining region Y)-box 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMEM45A transmembrane protein 45A
TNC tenascin C
TRIP6 thyroid hormone receptor interactor 6