BRD-K51575138_TPCA-1_MCF7_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

86 genes differentially expressed following the BRD-K51575138_TPCA-1_MCF7_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AEBP1 AE binding protein 1
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANPEP alanyl (membrane) aminopeptidase
ARG2 arginase 2
BCL2L1 BCL2-like 1
BCL6 B-cell CLL/lymphoma 6
BCL7A B-cell CLL/lymphoma 7A
CLU clusterin
COMT catechol-O-methyltransferase
CSTA cystatin A (stefin A)
CXCL9 chemokine (C-X-C motif) ligand 9
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
EXT1 exostosin glycosyltransferase 1
FADS1 fatty acid desaturase 1
FADS3 fatty acid desaturase 3
FAM134B family with sequence similarity 134, member B
GDF15 growth differentiation factor 15
GLDC glycine dehydrogenase (decarboxylating)
HIRA histone cell cycle regulator
HOXC6 homeobox C6
HSPB8 heat shock 22kDa protein 8
HYOU1 hypoxia up-regulated 1
KIAA0922 KIAA0922
LAT2 linker for activation of T cells family, member 2
LRRC41 leucine rich repeat containing 41
LYZ lysozyme
MME membrane metallo-endopeptidase
NNMT nicotinamide N-methyltransferase
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NT5E 5'-nucleotidase, ecto (CD73)
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
OSBPL10 oxysterol binding protein-like 10
PTK2 protein tyrosine kinase 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RND3 Rho family GTPase 3
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100A8 S100 calcium binding protein A8
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
TM9SF3 transmembrane 9 superfamily member 3
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TPD52L1 tumor protein D52-like 1
TRIM22 tripartite motif containing 22
TSPYL5 TSPY-like 5
TYMS thymidylate synthetase
ZBTB18 zinc finger and BTB domain containing 18
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
AGR2 anterior gradient 2
BAALC brain and acute leukemia, cytoplasmic
BPHL biphenyl hydrolase-like (serine hydrolase)
CKB creatine kinase, brain
COL4A5 collagen, type IV, alpha 5
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRABP1 cellular retinoic acid binding protein 1
DSG2 desmoglein 2
DSP desmoplakin
F3 coagulation factor III (thromboplastin, tissue factor)
FCGBP Fc fragment of IgG binding protein
IFITM1 interferon induced transmembrane protein 1
KLF6 Kruppel-like factor 6
KRT20 keratin 20, type I
LAGE3 L antigen family, member 3
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MLPH melanophilin
NUP62 nucleoporin 62kDa
PAEP progestagen-associated endometrial protein
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PIP prolactin-induced protein
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RPS5 ribosomal protein S5
SFN stratifin
SIRT3 sirtuin 3
SKP1 S-phase kinase-associated protein 1
SOSTDC1 sclerostin domain containing 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TTC3 tetratricopeptide repeat domain 3
UGDH UDP-glucose 6-dehydrogenase
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
WT1 Wilms tumor 1