BRD-K51575138_TPCA-1_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-K51575138_TPCA-1_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AREG amphiregulin
ARMCX1 armadillo repeat containing, X-linked 1
ATP11B ATPase, class VI, type 11B
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCAM basal cell adhesion molecule (Lutheran blood group)
BTG2 BTG family, member 2
C1QA complement component 1, q subcomponent, A chain
CAV1 caveolin 1, caveolae protein, 22kDa
CCND2 cyclin D2
CCNG1 cyclin G1
CD59 CD59 molecule, complement regulatory protein
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL4A5 collagen, type IV, alpha 5
CTGF connective tissue growth factor
CXCL9 chemokine (C-X-C motif) ligand 9
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DST dystonin
FAS Fas cell surface death receptor
FXYD3 FXYD domain containing ion transport regulator 3
GADD45A growth arrest and DNA-damage-inducible, alpha
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GLRX glutaredoxin (thioltransferase)
GSDMB gasdermin B
GSN gelsolin
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IER5 immediate early response 5
INHBB inhibin, beta B
ITGB5 integrin, beta 5
ITM2B integral membrane protein 2B
KIAA1324 KIAA1324
LAMP2 lysosomal-associated membrane protein 2
LXN latexin
NEBL nebulette
NUCB2 nucleobindin 2
PDE4DIP phosphodiesterase 4D interacting protein
PIP prolactin-induced protein
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PRUNE2 prune homolog 2 (Drosophila)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PYCARD PYD and CARD domain containing
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RTN2 reticulon 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SELENBP1 selenium binding protein 1
SESN1 sestrin 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SST somatostatin
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TMEM176B transmembrane protein 176B
TPP1 tripeptidyl peptidase I
TRIM22 tripartite motif containing 22
YBX3 Y box binding protein 3

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BID BH3 interacting domain death agonist
BIRC5 baculoviral IAP repeat containing 5
BLM Bloom syndrome, RecQ helicase-like
CCNF cyclin F
CDC6 cell division cycle 6
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CKS2 CDC28 protein kinase regulatory subunit 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
GTSE1 G-2 and S-phase expressed 1
HIST1H4C histone cluster 1, H4c
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
LMNB1 lamin B1
MAGEA1 melanoma antigen family A1
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MCM10 minichromosome maintenance complex component 10
MKI67 marker of proliferation Ki-67
NEK2 NIMA-related kinase 2
NUSAP1 nucleolar and spindle associated protein 1
PBK PDZ binding kinase
PITX1 paired-like homeodomain 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPC25 SPC25, NDC80 kinetochore complex component
SRC SRC proto-oncogene, non-receptor tyrosine kinase
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TACC3 transforming, acidic coiled-coil containing protein 3
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S