BRD-K51575138_TPCA-1_HA1E_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-K51575138_TPCA-1_HA1E_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT1 acetyl-CoA acetyltransferase 1
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ARHGAP29 Rho GTPase activating protein 29
ASNS asparagine synthetase (glutamine-hydrolyzing)
AZU1 azurocidin 1
BEX1 brain expressed, X-linked 1
CHD7 chromodomain helicase DNA binding protein 7
CHMP6 charged multivesicular body protein 6
CLEC11A C-type lectin domain family 11, member A
CLU clusterin
CST3 cystatin C
DEFB1 defensin, beta 1
DIRAS3 DIRAS family, GTP-binding RAS-like 3
EGR1 early growth response 1
ELANE elastase, neutrophil expressed
FBN2 fibrillin 2
FOSL2 FOS-like antigen 2
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GRB14 growth factor receptor-bound protein 14
HLA-DRA major histocompatibility complex, class II, DR alpha
HOXB6 homeobox B6
IGKC immunoglobulin kappa constant
IRS2 insulin receptor substrate 2
KIAA0100 KIAA0100
KRT18 keratin 18, type I
MALT1 MALT1 paracaspase
MBNL2 muscleblind-like splicing regulator 2
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
NAV3 neuron navigator 3
NDRG1 N-myc downstream regulated 1
NNMT nicotinamide N-methyltransferase
NR4A2 nuclear receptor subfamily 4, group A, member 2
PLK2 polo-like kinase 2
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
RAB31 RAB31, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS13 regulator of G-protein signaling 13
RHOA ras homolog family member A
S100P S100 calcium binding protein P
SEPP1 selenoprotein P, plasma, 1
SYBU syntabulin (syntaxin-interacting)
TMCO3 transmembrane and coiled-coil domains 3
TPD52L1 tumor protein D52-like 1
TSPAN8 tetraspanin 8
USP6NL USP6 N-terminal like
WDR1 WD repeat domain 1

decreased expression

Symbol Name
AK4 adenylate kinase 4
ATF3 activating transcription factor 3
CRABP1 cellular retinoic acid binding protein 1
CSRP2 cysteine and glycine-rich protein 2
CXCL14 chemokine (C-X-C motif) ligand 14
DPP4 dipeptidyl-peptidase 4
FABP4 fatty acid binding protein 4, adipocyte
GPM6B glycoprotein M6B
IER5 immediate early response 5
IFI16 interferon, gamma-inducible protein 16
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
KIAA0907 KIAA0907
LYPLA1 lysophospholipase I
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OASL 2'-5'-oligoadenylate synthetase-like
ORC1 origin recognition complex, subunit 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLAU plasminogen activator, urokinase
PPAP2B phosphatidic acid phosphatase type 2B
PROM1 prominin 1
RBPMS RNA binding protein with multiple splicing
RSAD2 radical S-adenosyl methionine domain containing 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON2 spondin 2, extracellular matrix protein
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF21 tumor necrosis factor receptor superfamily, member 21