BRD-K51556300_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

152 genes differentially expressed following the BRD-K51556300_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRE5 adhesion G protein-coupled receptor E5
ADIRF adipogenesis regulatory factor
AIM1 absent in melanoma 1
ARHGAP29 Rho GTPase activating protein 29
ARMCX2 armadillo repeat containing, X-linked 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
BLNK B-cell linker
CAPN2 calpain 2, (m/II) large subunit
CD38 CD38 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CFB complement factor B
CFD complement factor D (adipsin)
CHRDL1 chordin-like 1
CLDN3 claudin 3
CRABP2 cellular retinoic acid binding protein 2
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL6 chemokine (C-X-C motif) ligand 6
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EDNRB endothelin receptor type B
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
FABP6 fatty acid binding protein 6, ileal
FADS1 fatty acid desaturase 1
FAM13A family with sequence similarity 13, member A
FBLN5 fibulin 5
FKBP14 FK506 binding protein 14, 22 kDa
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GRK5 G protein-coupled receptor kinase 5
GULP1 GULP, engulfment adaptor PTB domain containing 1
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOXC6 homeobox C6
HSPA13 heat shock protein 70kDa family, member 13
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HYOU1 hypoxia up-regulated 1
IER3 immediate early response 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL15 interleukin 15
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KRT19 keratin 19, type I
KRT23 keratin 23, type I
LAPTM5 lysosomal protein transmembrane 5
LCK LCK proto-oncogene, Src family tyrosine kinase
LIPA lipase A, lysosomal acid, cholesterol esterase
LXN latexin
LY96 lymphocyte antigen 96
MAGED1 melanoma antigen family D1
MAN1A1 mannosidase, alpha, class 1A, member 1
MBNL2 muscleblind-like splicing regulator 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
MSMO1 methylsterol monooxygenase 1
NEFH neurofilament, heavy polypeptide
NEFL neurofilament, light polypeptide
NPTX2 neuronal pentraxin II
NT5E 5'-nucleotidase, ecto (CD73)
NTS neurotensin
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
OSBPL10 oxysterol binding protein-like 10
PCP4 Purkinje cell protein 4
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDIA3 protein disulfide isomerase family A, member 3
PDLIM4 PDZ and LIM domain 4
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLIN2 perilipin 2
PRKCDBP protein kinase C, delta binding protein
PROCR protein C receptor, endothelial
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RGS10 regulator of G-protein signaling 10
RNASE4 ribonuclease, RNase A family, 4
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCN3A sodium channel, voltage gated, type III alpha subunit
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDF2L1 stromal cell-derived factor 2-like 1
SEC24D SEC24 family member D
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SPON1 spondin 1, extracellular matrix protein
SQRDL sulfide quinone reductase-like (yeast)
SST somatostatin
SYNGR3 synaptogyrin 3
SYT1 synaptotagmin I
TAC1 tachykinin, precursor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM100 transmembrane protein 100
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPBG trophoblast glycoprotein
TPD52L1 tumor protein D52-like 1
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WFDC2 WAP four-disulfide core domain 2
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ASPN asporin
ATF5 activating transcription factor 5
CCND1 cyclin D1
CDC25A cell division cycle 25A
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CLDN18 claudin 18
CNPY3 canopy FGF signaling regulator 3
COL15A1 collagen, type XV, alpha 1
COL4A5 collagen, type IV, alpha 5
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
CXCL13 chemokine (C-X-C motif) ligand 13
CYTL1 cytokine-like 1
DAPK1 death-associated protein kinase 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
GLUL glutamate-ammonia ligase
GRWD1 glutamate-rich WD repeat containing 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IL1RN interleukin 1 receptor antagonist
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
NREP neuronal regeneration related protein
PDGFA platelet-derived growth factor alpha polypeptide
POSTN periostin, osteoblast specific factor
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RXRA retinoid X receptor, alpha
SATB1 SATB homeobox 1
SETBP1 SET binding protein 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRY2 sprouty homolog 2 (Drosophila)
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
ZCCHC2 zinc finger, CCHC domain containing 2