BRD-K51556300_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

218 genes differentially expressed following the BRD-K51556300_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ALDOB aldolase B, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
BTG1 B-cell translocation gene 1, anti-proliferative
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD14 CD14 molecule
CD163 CD163 molecule
CD36 CD36 molecule (thrombospondin receptor)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFD complement factor D (adipsin)
CLC Charcot-Leyden crystal galectin
COL1A1 collagen, type I, alpha 1
COL6A2 collagen, type VI, alpha 2
CPA3 carboxypeptidase A3 (mast cell)
CST3 cystatin C
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DGKA diacylglycerol kinase, alpha 80kDa
DHRS7 dehydrogenase/reductase (SDR family) member 7
ECM1 extracellular matrix protein 1
EFNA1 ephrin-A1
ENO2 enolase 2 (gamma, neuronal)
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F13A1 coagulation factor XIII, A1 polypeptide
FABP4 fatty acid binding protein 4, adipocyte
FADS2 fatty acid desaturase 2
FAM129A family with sequence similarity 129, member A
FBLN1 fibulin 1
FCGBP Fc fragment of IgG binding protein
FN1 fibronectin 1
FOXO4 forkhead box O4
GLRX glutaredoxin (thioltransferase)
HBB hemoglobin, beta
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IL32 interleukin 32
IRF9 interferon regulatory factor 9
LDOC1 leucine zipper, down-regulated in cancer 1
LOXL2 lysyl oxidase-like 2
LPAR6 lysophosphatidic acid receptor 6
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MT1X metallothionein 1X
NDRG1 N-myc downstream regulated 1
NELL2 NEL-like 2 (chicken)
NUCB2 nucleobindin 2
PAWR PRKC, apoptosis, WT1, regulator
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM3 PDZ and LIM domain 3
PDZK1IP1 PDZK1 interacting protein 1
PFKM phosphofructokinase, muscle
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAU plasminogen activator, urokinase
PLIN2 perilipin 2
PON3 paraoxonase 3
PPAP2B phosphatidic acid phosphatase type 2B
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRAF2 PRA1 domain family, member 2
PRSS8 protease, serine, 8
PRUNE2 prune homolog 2 (Drosophila)
PSAP prosaposin
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A14 S100 calcium binding protein A14
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP1 secreted frizzled-related protein 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNAI2 snail family zinc finger 2
SPON2 spondin 2, extracellular matrix protein
SST somatostatin
STC1 stanniocalcin 1
SYT1 synaptotagmin I
TIMP3 TIMP metallopeptidase inhibitor 3
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TSPAN5 tetraspanin 5
TWF2 twinfilin actin binding protein 2
TXNIP thioredoxin interacting protein
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAN versican
VIM vimentin
VSIG4 V-set and immunoglobulin domain containing 4
XIST X inactive specific transcript (non-protein coding)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPM centromere protein M
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHMP4A charged multivesicular body protein 4A
CHPT1 choline phosphotransferase 1
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
COCH cochlin
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL13 chemokine (C-X-C motif) ligand 13
DBF4 DBF4 zinc finger
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKC1 dyskeratosis congenita 1, dyskerin
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
EBNA1BP2 EBNA1 binding protein 2
EED embryonic ectoderm development
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5B eukaryotic translation initiation factor 5B
ENOPH1 enolase-phosphatase 1
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
HACD2 3-hydroxyacyl-CoA dehydratase 2
HMGB2 high mobility group box 2
HSPA4L heat shock 70kDa protein 4-like
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ICAM3 intercellular adhesion molecule 3
ISOC1 isochorismatase domain containing 1
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
KIAA0101 KIAA0101
KIAA0125 KIAA0125
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
LIG1 ligase I, DNA, ATP-dependent
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MBNL1 muscleblind-like splicing regulator 1
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MSMB microseminoprotein, beta-
MYCBP MYC binding protein
MYO5C myosin VC
NAT10 N-acetyltransferase 10 (GCN5-related)
NBN nibrin
NCAPH non-SMC condensin I complex, subunit H
NDC1 NDC1 transmembrane nucleoporin
NFIB nuclear factor I/B
NOLC1 nucleolar and coiled-body phosphoprotein 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
ODC1 ornithine decarboxylase 1
ORC6 origin recognition complex, subunit 6
OXTR oxytocin receptor
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAK1IP1 PAK1 interacting protein 1
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PLAGL1 pleiomorphic adenoma gene-like 1
PNN pinin, desmosome associated protein
PPIF peptidylprolyl isomerase F
PPIH peptidylprolyl isomerase H (cyclophilin H)
PRC1 protein regulator of cytokinesis 1
PRPF4 pre-mRNA processing factor 4
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTDSS1 phosphatidylserine synthase 1
RAB40B RAB40B, member RAS oncogene family
RAD54B RAD54 homolog B (S. cerevisiae)
RBM15 RNA binding motif protein 15
RFC2 replication factor C (activator 1) 2, 40kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM1 ribonucleotide reductase M1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRP1B ribosomal RNA processing 1B
SEH1L SEH1-like (S. cerevisiae)
SMC2 structural maintenance of chromosomes 2
SPDL1 spindle apparatus coiled-coil protein 1
SRSF7 serine/arginine-rich splicing factor 7
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TCL1A T-cell leukemia/lymphoma 1A
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIP13 thyroid hormone receptor interactor 13
TSPYL5 TSPY-like 5
TYMS thymidylate synthetase
UBAP2 ubiquitin associated protein 2
UBE2S ubiquitin-conjugating enzyme E2S
USP1 ubiquitin specific peptidase 1
VRK1 vaccinia related kinase 1
WDR1 WD repeat domain 1
WDR12 WD repeat domain 12
XBP1 X-box binding protein 1
XPO1 exportin 1
XPO7 exportin 7
ZWINT ZW10 interacting kinetochore protein