BRD-K51556300_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

107 genes differentially expressed following the BRD-K51556300_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD2 abhydrolase domain containing 2
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKAP12 A kinase (PRKA) anchor protein 12
AOX1 aldehyde oxidase 1
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ATHL1 ATH1, acid trehalase-like 1 (yeast)
C2CD2 C2 calcium-dependent domain containing 2
C3 complement component 3
CANX calnexin
CD59 CD59 molecule, complement regulatory protein
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CRIP1 cysteine-rich protein 1 (intestinal)
CSRP2 cysteine and glycine-rich protein 2
CTH cystathionine gamma-lyase
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EIF5A eukaryotic translation initiation factor 5A
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
F12 coagulation factor XII (Hageman factor)
FKBP11 FK506 binding protein 11, 19 kDa
FOXD1 forkhead box D1
G0S2 G0/G1 switch 2
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLS glutaminase
GPX3 glutathione peroxidase 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
IFI30 interferon, gamma-inducible protein 30
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL7R interleukin 7 receptor
INSIG1 insulin induced gene 1
IQGAP1 IQ motif containing GTPase activating protein 1
KIF14 kinesin family member 14
KLF2 Kruppel-like factor 2
LDLR low density lipoprotein receptor
LEF1 lymphoid enhancer-binding factor 1
LEPR leptin receptor
LPL lipoprotein lipase
MGLL monoglyceride lipase
MSMO1 methylsterol monooxygenase 1
MT1H metallothionein 1H
MT1X metallothionein 1X
MT2A metallothionein 2A
MTSS1 metastasis suppressor 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NRIP1 nuclear receptor interacting protein 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PDGFC platelet derived growth factor C
PHLDA1 pleckstrin homology-like domain, family A, member 1
PRR7 proline rich 7 (synaptic)
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
S100A10 S100 calcium binding protein A10
S100A8 S100 calcium binding protein A8
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCN3A sodium channel, voltage gated, type III alpha subunit
SELL selectin L
SGCE sarcoglycan, epsilon
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SPP1 secreted phosphoprotein 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SQLE squalene epoxidase
SRPX sushi-repeat containing protein, X-linked
STK10 serine/threonine kinase 10
SYT11 synaptotagmin XI
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMP4 TIMP metallopeptidase inhibitor 4
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM100 transmembrane protein 100
TSPAN8 tetraspanin 8
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
XBP1 X-box binding protein 1
ZIC1 Zic family member 1

decreased expression

Symbol Name
ACPP acid phosphatase, prostate
ACTG2 actin, gamma 2, smooth muscle, enteric
ADGRG6 adhesion G protein-coupled receptor G6
AUTS2 autism susceptibility candidate 2
BID BH3 interacting domain death agonist
CKB creatine kinase, brain
CLEC2B C-type lectin domain family 2, member B
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
CPE carboxypeptidase E
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DES desmin
DIO2 deiodinase, iodothyronine, type II
DKFZP586I1420 uncharacterized protein DKFZp586I1420
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
GAL galanin/GMAP prepropeptide
GJA1 gap junction protein, alpha 1, 43kDa
HOXA5 homeobox A5
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
LRMP lymphoid-restricted membrane protein
MEIS2 Meis homeobox 2
MMP13 matrix metallopeptidase 13
NEBL nebulette
PBX1 pre-B-cell leukemia homeobox 1
PPAP2B phosphatidic acid phosphatase type 2B
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
TMEM87A transmembrane protein 87A