BRD-K51454562_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

61 genes differentially expressed following the BRD-K51454562_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG6 adhesion G protein-coupled receptor G6
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ARG2 arginase 2
BMP4 bone morphogenetic protein 4
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DMXL2 Dmx-like 2
FTH1 ferritin, heavy polypeptide 1
GPX2 glutathione peroxidase 2
HSPA1A heat shock 70kDa protein 1A
HYOU1 hypoxia up-regulated 1
LGALS2 lectin, galactoside-binding, soluble, 2
LOC100505650 uncharacterized LOC100505650
MEST mesoderm specific transcript
MMP7 matrix metallopeptidase 7
MTMR11 myotubularin related protein 11
NR2F2 nuclear receptor subfamily 2, group F, member 2
OLFM4 olfactomedin 4
PDZK1 PDZ domain containing 1
PDZK1IP1 PDZK1 interacting protein 1
PSD3 pleckstrin and Sec7 domain containing 3
PTCH1 patched 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RTN1 reticulon 1
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAMP8 vesicle-associated membrane protein 8
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
CAV1 caveolin 1, caveolae protein, 22kDa
CD59 CD59 molecule, complement regulatory protein
EGFR epidermal growth factor receptor
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM46A family with sequence similarity 46, member A
FASN fatty acid synthase
GPNMB glycoprotein (transmembrane) nmb
GRB7 growth factor receptor-bound protein 7
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IL13RA2 interleukin 13 receptor, alpha 2
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
MFAP5 microfibrillar associated protein 5
PCOLCE procollagen C-endopeptidase enhancer
PLS3 plastin 3
PLTP phospholipid transfer protein
PRDX4 peroxiredoxin 4
SEPP1 selenoprotein P, plasma, 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SPRR1B small proline-rich protein 1B
SRPX sushi-repeat containing protein, X-linked
STK26 serine/threonine protein kinase 26
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN4 tetraspanin 4