BRD-K51443908_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

123 genes differentially expressed following the BRD-K51443908_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
APOLD1 apolipoprotein L domain containing 1
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BHLHE40 basic helix-loop-helix family, member e40
CCL4 chemokine (C-C motif) ligand 4
CCNA1 cyclin A1
CD93 CD93 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN2A cyclin-dependent kinase inhibitor 2A
CFB complement factor B
CLTC clathrin, heavy chain (Hc)
CXADR coxsackie virus and adenovirus receptor
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
EPCAM epithelial cell adhesion molecule
EPS8 epidermal growth factor receptor pathway substrate 8
EREG epiregulin
F11R F11 receptor
FABP4 fatty acid binding protein 4, adipocyte
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
GADD45B growth arrest and DNA-damage-inducible, beta
GCLC glutamate-cysteine ligase, catalytic subunit
GEM GTP binding protein overexpressed in skeletal muscle
GREM1 gremlin 1, DAN family BMP antagonist
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
INHBA inhibin, beta A
INHBB inhibin, beta B
JAG1 jagged 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MCL1 myeloid cell leukemia 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NMB neuromedin B
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PER1 period circadian clock 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLVAP plasmalemma vesicle associated protein
PMP22 peripheral myelin protein 22
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTPRK protein tyrosine phosphatase, receptor type, K
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RND3 Rho family GTPase 3
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIK1 salt-inducible kinase 1
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SOX9 SRY (sex determining region Y)-box 9
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STC1 stanniocalcin 1
STK38L serine/threonine kinase 38 like
SULF1 sulfatase 1
THBD thrombomodulin
TRIB1 tribbles pseudokinase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
ZFP36 ZFP36 ring finger protein
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
AURKA aurora kinase A
C2CD2 C2 calcium-dependent domain containing 2
CANT1 calcium activated nucleotidase 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXCL13 chemokine (C-X-C motif) ligand 13
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLG5 discs, large homolog 5 (Drosophila)
DLK1 delta-like 1 homolog (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
FAM178A family with sequence similarity 178, member A
FASTKD5 FAST kinase domains 5
FOLR1 folate receptor 1 (adult)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IQGAP2 IQ motif containing GTPase activating protein 2
KCTD12 potassium channel tetramerization domain containing 12
KIAA0907 KIAA0907
MTERF3 mitochondrial transcription termination factor 3
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PBX1 pre-B-cell leukemia homeobox 1
PRKCA protein kinase C, alpha
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAD54B RAD54 homolog B (S. cerevisiae)
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
TRAK2 trafficking protein, kinesin binding 2
TRBC1 T cell receptor beta constant 1
WT1 Wilms tumor 1