BRD-K51377689_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-K51377689_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
BLVRB biliverdin reductase B
CA12 carbonic anhydrase XII
CFI complement factor I
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
ELL2 elongation factor, RNA polymerase II, 2
EXOSC4 exosome component 4
G6PD glucose-6-phosphate dehydrogenase
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
KIAA0125 KIAA0125
LOC100505650 uncharacterized LOC100505650
MAP7 microtubule-associated protein 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NAMPT nicotinamide phosphoribosyltransferase
NDRG2 NDRG family member 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PTN pleiotrophin
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAD23B RAD23 homolog B (S. cerevisiae)
RGS2 regulator of G-protein signaling 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCG5 secretogranin V
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TKT transketolase
TPD52 tumor protein D52
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase
WBP5 WW domain binding protein 5

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
AKT3 v-akt murine thymoma viral oncogene homolog 3
ANXA3 annexin A3
AQP3 aquaporin 3 (Gill blood group)
ASS1 argininosuccinate synthase 1
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFD complement factor D (adipsin)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL11A1 collagen, type XI, alpha 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DHRS2 dehydrogenase/reductase (SDR family) member 2
DPYSL2 dihydropyrimidinase-like 2
EMP1 epithelial membrane protein 1
GAS6 growth arrest-specific 6
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GREM1 gremlin 1, DAN family BMP antagonist
HES1 hes family bHLH transcription factor 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL7R interleukin 7 receptor
KRT14 keratin 14, type I
KRT7 keratin 7, type II
LYZ lysozyme
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MFAP5 microfibrillar associated protein 5
NOV nephroblastoma overexpressed
NT5E 5'-nucleotidase, ecto (CD73)
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
TACSTD2 tumor-associated calcium signal transducer 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNS1 tensin 1
TOB1 transducer of ERBB2, 1
TRIM29 tripartite motif containing 29
TYRP1 tyrosinase-related protein 1