BRD-K51313569_palbociclib_MDAMB231_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

177 genes differentially expressed following the BRD-K51313569_palbociclib_MDAMB231_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AMIGO2 adhesion molecule with Ig-like domain 2
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CXCL8 chemokine (C-X-C motif) ligand 8
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
FBN2 fibrillin 2
FKBP1B FK506 binding protein 1B, 12.6 kDa
FN1 fibronectin 1
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GSTM3 glutathione S-transferase mu 3 (brain)
ITGAV integrin, alpha V
LAMB2 laminin, beta 2 (laminin S)
LDLR low density lipoprotein receptor
LDOC1 leucine zipper, down-regulated in cancer 1
LPCAT1 lysophosphatidylcholine acyltransferase 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MT1X metallothionein 1X
PALLD palladin, cytoskeletal associated protein
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TNS3 tensin 3
TUBA1A tubulin, alpha 1a

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
AUTS2 autism susceptibility candidate 2
BIRC5 baculoviral IAP repeat containing 5
BORA bora, aurora kinase A activator
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CBX5 chromobox homolog 5
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CCNE2 cyclin E2
CCNF cyclin F
CDC20 cell division cycle 20
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPM centromere protein M
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK1 checkpoint kinase 1
CKAP2 cytoskeleton associated protein 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
DBF4 DBF4 zinc finger
DEPDC1 DEP domain containing 1
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNA2 DNA replication helicase/nuclease 2
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DONSON downstream neighbor of SON
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
E2F8 E2F transcription factor 8
ECM1 extracellular matrix protein 1
ELF5 E74-like factor 5 (ets domain transcription factor)
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FANCI Fanconi anemia, complementation group I
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
FZD10 frizzled class receptor 10
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GMNN geminin, DNA replication inhibitor
GRIA2 glutamate receptor, ionotropic, AMPA 2
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HJURP Holliday junction recognition protein
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HSPA2 heat shock 70kDa protein 2
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
KIFC1 kinesin family member C1
KNTC1 kinetochore associated 1
KRT23 keratin 23, type I
LAMP5 lysosomal-associated membrane protein family, member 5
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MALL mal, T-cell differentiation protein-like
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEB nebulin
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NELL2 NEL-like 2 (chicken)
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSRC1 proline/serine-rich coiled-coil 1
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RAD51AP1 RAD51 associated protein 1
RBBP8 retinoblastoma binding protein 8
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RNASEH2A ribonuclease H2, subunit A
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SCGB2A2 secretoglobin, family 2A, member 2
SHCBP1 SHC SH2-domain binding protein 1
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SPRR3 small proline-rich protein 3
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TK1 thymidine kinase 1, soluble
TMEM97 transmembrane protein 97
TMPO thymopoietin
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TTK TTK protein kinase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
USP1 ubiquitin specific peptidase 1
VRK1 vaccinia related kinase 1
WHSC1 Wolf-Hirschhorn syndrome candidate 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein