BRD-K51313569_palbociclib_MDAMB231_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

68 genes differentially expressed following the BRD-K51313569_palbociclib_MDAMB231_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG2 adhesion G protein-coupled receptor G2
ALDOC aldolase C, fructose-bisphosphate
ARHGAP29 Rho GTPase activating protein 29
CHGB chromogranin B
DLK1 delta-like 1 homolog (Drosophila)
GPX3 glutathione peroxidase 3
GSTM3 glutathione S-transferase mu 3 (brain)
GYG2 glycogenin 2
IFI27 interferon, alpha-inducible protein 27
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
KRT19 keratin 19, type I
LAPTM5 lysosomal protein transmembrane 5
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAGED1 melanoma antigen family D1
NR2F6 nuclear receptor subfamily 2, group F, member 6
PECAM1 platelet/endothelial cell adhesion molecule 1
PIR pirin (iron-binding nuclear protein)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RNASET2 ribonuclease T2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SNAP25 synaptosomal-associated protein, 25kDa
SST somatostatin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP3 TIMP metallopeptidase inhibitor 3
TSPAN7 tetraspanin 7
VWF von Willebrand factor

decreased expression

Symbol Name
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
BAZ1A bromodomain adjacent to zinc finger domain, 1A
CCNA2 cyclin A2
CCNE2 cyclin E2
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
ECT2 epithelial cell transforming 2
EPHA3 EPH receptor A3
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FANCI Fanconi anemia, complementation group I
FOXM1 forkhead box M1
HIST1H4C histone cluster 1, H4c
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXA10 homeobox A10
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIF20A kinesin family member 20A
MELK maternal embryonic leucine zipper kinase
NCAPG2 non-SMC condensin II complex, subunit G2
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NUSAP1 nucleolar and spindle associated protein 1
PBK PDZ binding kinase
PLK1 polo-like kinase 1
PRC1 protein regulator of cytokinesis 1
PRR15L proline rich 15-like
RACGAP1 Rac GTPase activating protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
SMC2 structural maintenance of chromosomes 2
TACC3 transforming, acidic coiled-coil containing protein 3
TOP2A topoisomerase (DNA) II alpha 170kDa