BRD-K51313569_palbociclib_LNCAP_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

70 genes differentially expressed following the BRD-K51313569_palbociclib_LNCAP_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP8L A kinase (PRKA) anchor protein 8-like
ANXA9 annexin A9
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CA12 carbonic anhydrase XII
CDC20 cell division cycle 20
CLU clusterin
CXCL12 chemokine (C-X-C motif) ligand 12
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FBN2 fibrillin 2
HBD hemoglobin, delta
HIST1H2BD histone cluster 1, H2bd
IFITM1 interferon induced transmembrane protein 1
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT5 keratin 5, type II
KRT7 keratin 7, type II
LUM lumican
NPY1R neuropeptide Y receptor Y1
PDLIM5 PDZ and LIM domain 5
POSTN periostin, osteoblast specific factor
PXDN peroxidasin
PYCARD PYD and CARD domain containing
RAB29 RAB29, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SFRP1 secreted frizzled-related protein 1
STC2 stanniocalcin 2
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TPD52L1 tumor protein D52-like 1
VPREB3 pre-B lymphocyte 3
ZNF185 zinc finger protein 185 (LIM domain)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADAM28 ADAM metallopeptidase domain 28
ANOS1 anosmin 1
AQP1 aquaporin 1 (Colton blood group)
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F2 E2F transcription factor 2
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EMP1 epithelial membrane protein 1
GMNN geminin, DNA replication inhibitor
GREM1 gremlin 1, DAN family BMP antagonist
HMG20B high mobility group 20B
HOXD1 homeobox D1
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
MEF2C myocyte enhancer factor 2C
MMP7 matrix metallopeptidase 7
NOTCH2NL notch 2 N-terminal like
NQO2 NAD(P)H dehydrogenase, quinone 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PCSK1 proprotein convertase subtilisin/kexin type 1
PRKD3 protein kinase D3
PTCH1 patched 1
RAD51AP1 RAD51 associated protein 1
RHOBTB3 Rho-related BTB domain containing 3
RRM2 ribonucleotide reductase M2
SFTPB surfactant protein B
SMAD3 SMAD family member 3
SPEN spen family transcriptional repressor
TDO2 tryptophan 2,3-dioxygenase
TOX3 TOX high mobility group box family member 3
WNT5A wingless-type MMTV integration site family, member 5A