BRD-K51313569_palbociclib_LNCAP_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

175 genes differentially expressed following the BRD-K51313569_palbociclib_LNCAP_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADIRF adipogenesis regulatory factor
ANXA2 annexin A2
AZU1 azurocidin 1
BHLHE41 basic helix-loop-helix family, member e41
BIK BCL2-interacting killer (apoptosis-inducing)
CAPN2 calpain 2, (m/II) large subunit
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHGB chromogranin B
CLU clusterin
EPCAM epithelial cell adhesion molecule
IFI27 interferon, alpha-inducible protein 27
KRT19 keratin 19, type I
LGALS3 lectin, galactoside-binding, soluble, 3
MAMLD1 mastermind-like domain containing 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MXRA5 matrix-remodelling associated 5
MYO6 myosin VI
NPY1R neuropeptide Y receptor Y1
PYCARD PYD and CARD domain containing
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RBP1 retinol binding protein 1, cellular
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RPL39L ribosomal protein L39-like
STAR steroidogenic acute regulatory protein
SYT1 synaptotagmin I
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TST thiosulfate sulfurtransferase (rhodanese)
VCAN versican

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ADM adrenomedullin
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
BARD1 BRCA1 associated RING domain 1
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB3 BUB3 mitotic checkpoint protein
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNE2 cyclin E2
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDC45 cell division cycle 45
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN3 cyclin-dependent kinase inhibitor 3
CDT1 chromatin licensing and DNA replication factor 1
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK1 checkpoint kinase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIT citron rho-interacting serine/threonine kinase
CSRP2 cysteine and glycine-rich protein 2
DCK deoxycytidine kinase
DEK DEK proto-oncogene
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DONSON downstream neighbor of SON
DPYD dihydropyrimidine dehydrogenase
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F2 E2F transcription factor 2
ECT2 epithelial cell transforming 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCG Fanconi anemia, complementation group G
FANCI Fanconi anemia, complementation group I
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GDF15 growth differentiation factor 15
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GMNN geminin, DNA replication inhibitor
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPSM2 G-protein signaling modulator 2
GTSE1 G-2 and S-phase expressed 1
GUCY1B3 guanylate cyclase 1, soluble, beta 3
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HELLS helicase, lymphoid-specific
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
KIFC1 kinesin family member C1
LMNB1 lamin B1
LOXL2 lysyl oxidase-like 2
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MMP9 matrix metallopeptidase 9
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYLK myosin light chain kinase
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NMU neuromedin U
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDLIM1 PDZ and LIM domain 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSRC1 proline/serine-rich coiled-coil 1
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RAD51AP1 RAD51 associated protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGCC regulator of cell cycle
RNASEH2A ribonuclease H2, subunit A
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SOX11 SRY (sex determining region Y)-box 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPC25 SPC25, NDC80 kinetochore complex component
SPP1 secreted phosphoprotein 1
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMEM194A transmembrane protein 194A
TMPO thymopoietin
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRMT5 tRNA methyltransferase 5
TROAP trophinin associated protein
TTK TTK protein kinase
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein