BRD-K51313569_palbociclib_HT29_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

128 genes differentially expressed following the BRD-K51313569_palbociclib_HT29_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADIRF adipogenesis regulatory factor
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA3 annexin A3
ARMCX2 armadillo repeat containing, X-linked 2
ATP2A3 ATPase, Ca++ transporting, ubiquitous
AZU1 azurocidin 1
BEX1 brain expressed, X-linked 1
BST2 bone marrow stromal cell antigen 2
C1ORF106 chromosome 1 open reading frame 106
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CCNG2 cyclin G2
CD36 CD36 molecule (thrombospondin receptor)
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHRDL1 chordin-like 1
CTSG cathepsin G
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
ECHDC2 enoyl CoA hydratase domain containing 2
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
F13A1 coagulation factor XIII, A1 polypeptide
FABP4 fatty acid binding protein 4, adipocyte
FLRT3 fibronectin leucine rich transmembrane protein 3
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
HLA-B major histocompatibility complex, class I, B
HLA-E major histocompatibility complex, class I, E
HLA-G major histocompatibility complex, class I, G
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MFAP5 microfibrillar associated protein 5
MSLN mesothelin
MT1E metallothionein 1E
MT1X metallothionein 1X
MVP major vault protein
MX1 MX dynamin-like GTPase 1
NEFH neurofilament, heavy polypeptide
NPDC1 neural proliferation, differentiation and control, 1
PALLD palladin, cytoskeletal associated protein
PLA2G16 phospholipase A2, group XVI
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PRKCI protein kinase C, iota
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
SLIT2 slit homolog 2 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
SST somatostatin
TACC2 transforming, acidic coiled-coil containing protein 2
TACSTD2 tumor-associated calcium signal transducer 2
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TMEM100 transmembrane protein 100
TSPAN8 tetraspanin 8
TTC39A tetratricopeptide repeat domain 39A
WFS1 Wolfram syndrome 1 (wolframin)

decreased expression

Symbol Name
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
FOXM1 forkhead box M1
FSCN1 fascin actin-bundling protein 1
FXYD5 FXYD domain containing ion transport regulator 5
GLIPR1 GLI pathogenesis-related 1
H2AFV H2A histone family, member V
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HPRT1 hypoxanthine phosphoribosyltransferase 1
KIF20A kinesin family member 20A
KRT15 keratin 15, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LBR lamin B receptor
MALL mal, T-cell differentiation protein-like
MKI67 marker of proliferation Ki-67
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MTSS1 metastasis suppressor 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYLK myosin light chain kinase
NELL2 NEL-like 2 (chicken)
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NRGN neurogranin (protein kinase C substrate, RC3)
NUSAP1 nucleolar and spindle associated protein 1
PLK1 polo-like kinase 1
PRC1 protein regulator of cytokinesis 1
PSIP1 PC4 and SFRS1 interacting protein 1
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RAI14 retinoic acid induced 14
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RUNX3 runt-related transcription factor 3
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
STMN1 stathmin 1
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TSPYL5 TSPY-like 5
UBE2C ubiquitin-conjugating enzyme E2C
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)