BRD-K51313569_palbociclib_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

120 genes differentially expressed following the BRD-K51313569_palbociclib_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRL2 adhesion G protein-coupled receptor L2
AKAP12 A kinase (PRKA) anchor protein 12
ALCAM activated leukocyte cell adhesion molecule
ANXA6 annexin A6
BHLHE41 basic helix-loop-helix family, member e41
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHI3L2 chitinase 3-like 2
COL4A5 collagen, type IV, alpha 5
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DEGS1 delta(4)-desaturase, sphingolipid 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ERBB4 erb-b2 receptor tyrosine kinase 4
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FAM171A1 family with sequence similarity 171, member A1
FAS Fas cell surface death receptor
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GSTA4 glutathione S-transferase alpha 4
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP7 insulin-like growth factor binding protein 7
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
MX1 MX dynamin-like GTPase 1
MXRA5 matrix-remodelling associated 5
NCALD neurocalcin delta
NEBL nebulette
NPDC1 neural proliferation, differentiation and control, 1
NUPR1 nuclear protein, transcriptional regulator, 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDIA3 protein disulfide isomerase family A, member 3
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PLS3 plastin 3
PNMAL1 paraneoplastic Ma antigen family-like 1
PRR7 proline rich 7 (synaptic)
PTCH1 patched 1
PTPRM protein tyrosine phosphatase, receptor type, M
RAB29 RAB29, member RAS oncogene family
RBP1 retinol binding protein 1, cellular
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS5 regulator of G-protein signaling 5
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPP38 ribonuclease P/MRP 38kDa subunit
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SH3BGRL SH3 domain binding glutamate-rich protein like
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TMEM45A transmembrane protein 45A
TMEM87A transmembrane protein 87A
TMPRSS3 transmembrane protease, serine 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRPS1 trichorhinophalangeal syndrome I
TSPAN6 tetraspanin 6
TXNDC9 thioredoxin domain containing 9
VIM vimentin
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ADM adrenomedullin
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
AUTS2 autism susceptibility candidate 2
BIRC5 baculoviral IAP repeat containing 5
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CHEK2 checkpoint kinase 2
COL2A1 collagen, type II, alpha 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNMT1 DNA (cytosine-5-)-methyltransferase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EREG epiregulin
GINS2 GINS complex subunit 2 (Psf2 homolog)
HIST1H2BG histone cluster 1, H2bg
HMGB3 high mobility group box 3
HPRT1 hypoxanthine phosphoribosyltransferase 1
IGHM immunoglobulin heavy constant mu
JADE2 jade family PHD finger 2
LYPD1 LY6/PLAUR domain containing 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MALL mal, T-cell differentiation protein-like
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POU4F1 POU class 4 homeobox 1
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PSIP1 PC4 and SFRS1 interacting protein 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTPRK protein tyrosine phosphatase, receptor type, K
PXMP2 peroxisomal membrane protein 2, 22kDa
RPIA ribose 5-phosphate isomerase A
SEH1L SEH1-like (S. cerevisiae)
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TIMP3 TIMP metallopeptidase inhibitor 3
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UGCG UDP-glucose ceramide glucosyltransferase
XYLT1 xylosyltransferase I
ZNF292 zinc finger protein 292