BRD-K51313569_palbociclib_BT20_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

207 genes differentially expressed following the BRD-K51313569_palbociclib_BT20_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
AKR1C3 aldo-keto reductase family 1, member C3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BCL6 B-cell CLL/lymphoma 6
BHLHE41 basic helix-loop-helix family, member e41
BLVRB biliverdin reductase B
BPGM 2,3-bisphosphoglycerate mutase
BST2 bone marrow stromal cell antigen 2
CA2 carbonic anhydrase II
CD59 CD59 molecule, complement regulatory protein
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFB complement factor B
CLIC3 chloride intracellular channel 3
CLU clusterin
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DSE dermatan sulfate epimerase
DUSP6 dual specificity phosphatase 6
FOLR1 folate receptor 1 (adult)
GSDMB gasdermin B
HBB hemoglobin, beta
HBD hemoglobin, delta
HIST1H1C histone cluster 1, H1c
HMOX1 heme oxygenase 1
IDS iduronate 2-sulfatase
IGHM immunoglobulin heavy constant mu
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KIAA1551 KIAA1551
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LTBP1 latent transforming growth factor beta binding protein 1
LTBP3 latent transforming growth factor beta binding protein 3
LXN latexin
LY75 lymphocyte antigen 75
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAGED1 melanoma antigen family D1
MAGED2 melanoma antigen family D2
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
NPY1R neuropeptide Y receptor Y1
OBSL1 obscurin-like 1
PLAC8 placenta-specific 8
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PON2 paraoxonase 2
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
QPRT quinolinate phosphoribosyltransferase
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCPEP1 serine carboxypeptidase 1
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLPI secretory leukocyte peptidase inhibitor
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASPN asporin
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
AXL AXL receptor tyrosine kinase
BACE2 beta-site APP-cleaving enzyme 2
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CALR calreticulin
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CIT citron rho-interacting serine/threonine kinase
CKS1B CDC28 protein kinase regulatory subunit 1B
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
DDAH1 dimethylarginine dimethylaminohydrolase 1
DEGS1 delta(4)-desaturase, sphingolipid 1
DEK DEK proto-oncogene
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ENO1 enolase 1, (alpha)
EPCAM epithelial cell adhesion molecule
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM64A family with sequence similarity 64, member A
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GAL galanin/GMAP prepropeptide
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNAS GNAS complex locus
GPNMB glycoprotein (transmembrane) nmb
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HJURP Holliday junction recognition protein
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMGN2 high mobility group nucleosomal binding domain 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
IGFBP7 insulin-like growth factor binding protein 7
IGL immunoglobulin lambda locus
IRS2 insulin receptor substrate 2
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT5 keratin 5, type II
LBR lamin B receptor
LMNB2 lamin B2
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MFAP5 microfibrillar associated protein 5
MKI67 marker of proliferation Ki-67
MOXD1 monooxygenase, DBH-like 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYLK myosin light chain kinase
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NFIB nuclear factor I/B
NID1 nidogen 1
NUSAP1 nucleolar and spindle associated protein 1
PBK PDZ binding kinase
PLK1 polo-like kinase 1
PLS3 plastin 3
PRC1 protein regulator of cytokinesis 1
PSIP1 PC4 and SFRS1 interacting protein 1
PTMA prothymosin, alpha
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RAD51AP1 RAD51 associated protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
SDC2 syndecan 2
SFN stratifin
SMC4 structural maintenance of chromosomes 4
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STMN1 stathmin 1
SULF1 sulfatase 1
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TRMT5 tRNA methyltransferase 5
TROAP trophinin associated protein
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
USP1 ubiquitin specific peptidase 1
WHSC1 Wolf-Hirschhorn syndrome candidate 1
WSB2 WD repeat and SOCS box containing 2
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein