BRD-K51313569_palbociclib_BT20_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

109 genes differentially expressed following the BRD-K51313569_palbociclib_BT20_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAA1 acetyl-CoA acyltransferase 1
AGR2 anterior gradient 2
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALOX5AP arachidonate 5-lipoxygenase-activating protein
BCL6 B-cell CLL/lymphoma 6
C3 complement component 3
CES1 carboxylesterase 1
CFB complement factor B
CLU clusterin
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DLK1 delta-like 1 homolog (Drosophila)
DUSP10 dual specificity phosphatase 10
FGG fibrinogen gamma chain
FXYD3 FXYD domain containing ion transport regulator 3
GATA3 GATA binding protein 3
GCLC glutamate-cysteine ligase, catalytic subunit
GLRX glutaredoxin (thioltransferase)
GSAP gamma-secretase activating protein
GSTA4 glutathione S-transferase alpha 4
HMOX1 heme oxygenase 1
IRF6 interferon regulatory factor 6
LTBP1 latent transforming growth factor beta binding protein 1
LTF lactotransferrin
MAP7 microtubule-associated protein 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MERTK MER proto-oncogene, tyrosine kinase
MVP major vault protein
NAMPT nicotinamide phosphoribosyltransferase
NARS asparaginyl-tRNA synthetase
NEBL nebulette
PON3 paraoxonase 3
PPAP2B phosphatidic acid phosphatase type 2B
PTGER4 prostaglandin E receptor 4 (subtype EP4)
QPCT glutaminyl-peptide cyclotransferase
RPS4Y1 ribosomal protein S4, Y-linked 1
SELENBP1 selenium binding protein 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIB2 tribbles pseudokinase 2
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
TSPAN6 tetraspanin 6
VAV3 vav 3 guanine nucleotide exchange factor
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
ANXA1 annexin A1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
C14ORF132 chromosome 14 open reading frame 132
CAB39 calcium binding protein 39
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCNF cyclin F
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CEMIP cell migration inducing protein, hyaluronan binding
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
COL6A2 collagen, type VI, alpha 2
CPE carboxypeptidase E
CXCL14 chemokine (C-X-C motif) ligand 14
DEK DEK proto-oncogene
DERA deoxyribose-phosphate aldolase (putative)
FAM129A family with sequence similarity 129, member A
FHL1 four and a half LIM domains 1
FOXM1 forkhead box M1
H2AFV H2A histone family, member V
HIST1H4C histone cluster 1, H4c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGB2 high mobility group box 2
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
LOXL2 lysyl oxidase-like 2
MATN2 matrilin 2
MELK maternal embryonic leucine zipper kinase
MRPL19 mitochondrial ribosomal protein L19
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NMU neuromedin U
OSBPL8 oxysterol binding protein-like 8
PLK1 polo-like kinase 1
PSRC1 proline/serine-rich coiled-coil 1
PTMA prothymosin, alpha
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SDC2 syndecan 2
SPDL1 spindle apparatus coiled-coil protein 1
TMF1 TATA element modulatory factor 1
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TUBB2A tubulin, beta 2A class IIa
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
ZEB1 zinc finger E-box binding homeobox 1