BRD-K51313569_palbociclib_A549_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

154 genes differentially expressed following the BRD-K51313569_palbociclib_A549_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACADVL acyl-CoA dehydrogenase, very long chain
AK4 adenylate kinase 4
AMIGO2 adhesion molecule with Ig-like domain 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA4 annexin A4
APOA1 apolipoprotein A-I
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CCDC92 coiled-coil domain containing 92
CD59 CD59 molecule, complement regulatory protein
CYFIP1 cytoplasmic FMR1 interacting protein 1
DSP desmoplakin
EGFR epidermal growth factor receptor
EPAS1 endothelial PAS domain protein 1
FAM127A family with sequence similarity 127, member A
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FN1 fibronectin 1
GCLC glutamate-cysteine ligase, catalytic subunit
GLS glutaminase
GSAP gamma-secretase activating protein
GSN gelsolin
HBD hemoglobin, delta
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGKC immunoglobulin kappa constant
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
JAG1 jagged 1
KRT18 keratin 18, type I
KRT8 keratin 8, type II
KYNU kynureninase
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIMCH1 LIM and calponin homology domains 1
LXN latexin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MVP major vault protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPR3 natriuretic peptide receptor 3
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OPN3 opsin 3
OSMR oncostatin M receptor
PERP PERP, TP53 apoptosis effector
RAB40B RAB40B, member RAS oncogene family
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SIDT2 SID1 transmembrane family, member 2
SLC22A18 solute carrier family 22, member 18
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SNAP25 synaptosomal-associated protein, 25kDa
SYNGR3 synaptogyrin 3
TARP TCR gamma alternate reading frame protein
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TPM2 tropomyosin 2 (beta)
TRAPPC6A trafficking protein particle complex 6A
VCAN versican
VDAC1 voltage-dependent anion channel 1

decreased expression

Symbol Name
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ARHGAP29 Rho GTPase activating protein 29
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C14ORF132 chromosome 14 open reading frame 132
CBX3 chromobox homolog 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CCP110 centriolar coiled coil protein 110kDa
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN3 cyclin-dependent kinase inhibitor 3
CEMIP cell migration inducing protein, hyaluronan binding
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPN centromere protein N
CEP55 centrosomal protein 55kDa
CKS2 CDC28 protein kinase regulatory subunit 2
CLEC2B C-type lectin domain family 2, member B
DBF4 DBF4 zinc finger
DEK DEK proto-oncogene
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DSCC1 DNA replication and sister chromatid cohesion 1
FANCI Fanconi anemia, complementation group I
FBXO5 F-box protein 5
FOXM1 forkhead box M1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GREB1 growth regulation by estrogen in breast cancer 1
GTSE1 G-2 and S-phase expressed 1
H2AFV H2A histone family, member V
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
KIAA0226L KIAA0226-like
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KLHL7 kelch-like family member 7
LMNB1 lamin B1
LMNB2 lamin B2
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LY96 lymphocyte antigen 96
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MMP3 matrix metallopeptidase 3
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PLK4 polo-like kinase 4
PRC1 protein regulator of cytokinesis 1
PTMA prothymosin, alpha
RAD51AP1 RAD51 associated protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RPA3 replication protein A3, 14kDa
SHCBP1 SHC SH2-domain binding protein 1
SMC4 structural maintenance of chromosomes 4
SNRPG small nuclear ribonucleoprotein polypeptide G
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TMPO thymopoietin
TMSB15A thymosin beta 15a
TPX2 TPX2, microtubule-associated
TXN thioredoxin
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
USP1 ubiquitin specific peptidase 1
WHSC1 Wolf-Hirschhorn syndrome candidate 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)