BRD-K51313569_palbociclib_A549_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

84 genes differentially expressed following the BRD-K51313569_palbociclib_A549_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AGTR1 angiotensin II receptor, type 1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APOL1 apolipoprotein L, 1
AQP1 aquaporin 1 (Colton blood group)
BPIFA1 BPI fold containing family A, member 1
CD14 CD14 molecule
CFB complement factor B
COLEC12 collectin sub-family member 12
CPB1 carboxypeptidase B1 (tissue)
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYB5R1 cytochrome b5 reductase 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPYSL2 dihydropyrimidinase-like 2
ETV5 ets variant 5
FAM198B family with sequence similarity 198, member B
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FGL2 fibrinogen-like 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
ICAM2 intercellular adhesion molecule 2
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
ISG15 ISG15 ubiquitin-like modifier
KCTD12 potassium channel tetramerization domain containing 12
KRT7 keratin 7, type II
LDOC1 leucine zipper, down-regulated in cancer 1
LIMCH1 LIM and calponin homology domains 1
LMO2 LIM domain only 2 (rhombotin-like 1)
LUM lumican
MARCKS myristoylated alanine-rich protein kinase C substrate
MOAP1 modulator of apoptosis 1
MTSS1 metastasis suppressor 1
MX1 MX dynamin-like GTPase 1
NEBL nebulette
NNMT nicotinamide N-methyltransferase
NREP neuronal regeneration related protein
NRGN neurogranin (protein kinase C substrate, RC3)
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLK2 polo-like kinase 2
PMP22 peripheral myelin protein 22
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PROM1 prominin 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS4 regulator of G-protein signaling 4
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A8 S100 calcium binding protein A8
SDC4 syndecan 4
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLPI secretory leukocyte peptidase inhibitor
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS1 thrombospondin 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TWIST1 twist family bHLH transcription factor 1
UPK1B uroplakin 1B
VNN1 vanin 1

decreased expression

Symbol Name
CCNA2 cyclin A2
CCND2 cyclin D2
CENPU centromere protein U
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DHRS2 dehydrogenase/reductase (SDR family) member 2
G0S2 G0/G1 switch 2
GREB1 growth regulation by estrogen in breast cancer 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSPA2 heat shock 70kDa protein 2
KIF14 kinesin family member 14
LEFTY1 left-right determination factor 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LOXL1 lysyl oxidase-like 1
MMP9 matrix metallopeptidase 9
PCDH9 protocadherin 9
RAD23B RAD23 homolog B (S. cerevisiae)
REG3A regenerating islet-derived 3 alpha
TOR1A torsin family 1, member A (torsin A)
UGDH UDP-glucose 6-dehydrogenase
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)