BRD-K51313569_HY-50767_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

194 genes differentially expressed following the BRD-K51313569_HY-50767_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
ANXA4 annexin A4
APOD apolipoprotein D
BEX4 brain expressed, X-linked 4
CCDC92 coiled-coil domain containing 92
CCNG2 cyclin G2
CD44 CD44 molecule (Indian blood group)
CD47 CD47 molecule
CFD complement factor D (adipsin)
CHGB chromogranin B
COL4A5 collagen, type IV, alpha 5
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
F13A1 coagulation factor XIII, A1 polypeptide
GNAS GNAS complex locus
HLA-E major histocompatibility complex, class I, E
KRT19 keratin 19, type I
LCN2 lipocalin 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MME membrane metallo-endopeptidase
MVP major vault protein
NPY1R neuropeptide Y receptor Y1
NRCAM neuronal cell adhesion molecule
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
QPCT glutaminyl-peptide cyclotransferase
RGS2 regulator of G-protein signaling 2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPON2 spondin 2, extracellular matrix protein
SRPX sushi-repeat containing protein, X-linked
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TXNIP thioredoxin interacting protein
WLS wntless Wnt ligand secretion mediator
ZFP36L2 ZFP36 ring finger protein-like 2
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
AK4 adenylate kinase 4
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARMT1 acidic residue methyltransferase 1
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C7 complement component 7
CALR calreticulin
CALU calumenin
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CDT1 chromatin licensing and DNA replication factor 1
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPM centromere protein M
CENPN centromere protein N
CEP55 centrosomal protein 55kDa
CHAF1B chromatin assembly factor 1, subunit B (p60)
CKS1B CDC28 protein kinase regulatory subunit 1B
CNOT7 CCR4-NOT transcription complex, subunit 7
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DEPDC1 DEP domain containing 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF4B eukaryotic translation initiation factor 4B
EREG epiregulin
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXO1 exonuclease 1
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FGFR1OP FGFR1 oncogene partner
FGFR3 fibroblast growth factor receptor 3
FOXM1 forkhead box M1
GABPB1 GA binding protein transcription factor, beta subunit 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
H2AFZ H2A histone family, member Z
HELLS helicase, lymphoid-specific
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KIFC1 kinesin family member C1
KLF4 Kruppel-like factor 4 (gut)
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MIS18A MIS18 kinetochore protein A
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21
OIP5 Opa interacting protein 5
OXA1L oxidase (cytochrome c) assembly 1-like
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PGAM1 phosphoglycerate mutase 1 (brain)
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PROM1 prominin 1
PSRC1 proline/serine-rich coiled-coil 1
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PTTG1 pituitary tumor-transforming 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RACGAP1 Rac GTPase activating protein 1
RAD51 RAD51 recombinase
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNASEH2A ribonuclease H2, subunit A
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
SDC2 syndecan 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SET SET nuclear proto-oncogene
SHCBP1 SHC SH2-domain binding protein 1
SIVA1 SIVA1, apoptosis-inducing factor
SKA1 spindle and kinetochore associated complex subunit 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMC2 structural maintenance of chromosomes 2
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
STIL SCL/TAL1 interrupting locus
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TK1 thymidine kinase 1, soluble
TLR4 toll-like receptor 4
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TTK TTK protein kinase
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
ZWINT ZW10 interacting kinetochore protein