BRD-K51290057_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

180 genes differentially expressed following the BRD-K51290057_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD4 abhydrolase domain containing 4
ADGRG2 adhesion G protein-coupled receptor G2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANGPT1 angiopoietin 1
ANXA10 annexin A10
ANXA4 annexin A4
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BLVRB biliverdin reductase B
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL5 chemokine (C-C motif) ligand 5
CD8A CD8a molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRDL1 chordin-like 1
COL11A1 collagen, type XI, alpha 1
CRTAC1 cartilage acidic protein 1
CTSK cathepsin K
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYSL3 dihydropyrimidinase-like 3
DUSP4 dual specificity phosphatase 4
FAM13A family with sequence similarity 13, member A
FAM63A family with sequence similarity 63, member A
FBLN1 fibulin 1
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FRZB frizzled-related protein
FTH1 ferritin, heavy polypeptide 1
FZD7 frizzled class receptor 7
GAREM GRB2 associated, regulator of MAPK1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GOLPH3L golgi phosphoprotein 3-like
GPM6B glycoprotein M6B
GPX2 glutathione peroxidase 2
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBB hemoglobin, beta
HBD hemoglobin, delta
HMOX1 heme oxygenase 1
HOXA4 homeobox A4
HOXA5 homeobox A5
HOXA7 homeobox A7
HOXB2 homeobox B2
HOXB5 homeobox B5
HOXB7 homeobox B7
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM2 intercellular adhesion molecule 2
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGL immunoglobulin lambda locus
JCHAIN joining chain of multimeric IgA and IgM
KAZN kazrin, periplakin interacting protein
KLHDC2 kelch domain containing 2
KRT13 keratin 13, type I
KRT19 keratin 19, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIMCH1 LIM and calponin homology domains 1
LOXL1 lysyl oxidase-like 1
LXN latexin
MAN1A1 mannosidase, alpha, class 1A, member 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METTL7A methyltransferase like 7A
MFAP2 microfibrillar-associated protein 2
MFAP4 microfibrillar-associated protein 4
MYC v-myc avian myelocytomatosis viral oncogene homolog
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NQO1 NAD(P)H dehydrogenase, quinone 1
NRIP1 nuclear receptor interacting protein 1
PCSK5 proprotein convertase subtilisin/kexin type 5
PDGFD platelet derived growth factor D
PIR pirin (iron-binding nuclear protein)
PLBD1 phospholipase B domain containing 1
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLIN2 perilipin 2
PPARG peroxisome proliferator-activated receptor gamma
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
PSAP prosaposin
PTX3 pentraxin 3, long
RAP1GAP RAP1 GTPase activating protein
RBKS ribokinase
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
SDC1 syndecan 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFRP4 secreted frizzled-related protein 4
SKAP2 src kinase associated phosphoprotein 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SMAD3 SMAD family member 3
SNAI2 snail family zinc finger 2
SQSTM1 sequestosome 1
TAC1 tachykinin, precursor 1
TCEA2 transcription elongation factor A (SII), 2
TKT transketolase
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRIM16 tripartite motif containing 16
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1
UPP1 uridine phosphorylase 1
VCAM1 vascular cell adhesion molecule 1
WARS tryptophanyl-tRNA synthetase
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
AGR2 anterior gradient 2
AHSG alpha-2-HS-glycoprotein
APOA2 apolipoprotein A-II
ARID5B AT rich interactive domain 5B (MRF1-like)
C3 complement component 3
CD59 CD59 molecule, complement regulatory protein
CLDN3 claudin 3
CNN3 calponin 3, acidic
COL4A2 collagen, type IV, alpha 2
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DLK1 delta-like 1 homolog (Drosophila)
DMD dystrophin
EFHD1 EF-hand domain family, member D1
EREG epiregulin
ESR1 estrogen receptor 1
EVL Enah/Vasp-like
F3 coagulation factor III (thromboplastin, tissue factor)
FGF9 fibroblast growth factor 9
GREB1 growth regulation by estrogen in breast cancer 1
HAL histidine ammonia-lyase
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP7 insulin-like growth factor binding protein 7
ISG15 ISG15 ubiquitin-like modifier
KIF5B kinesin family member 5B
KRT1 keratin 1, type II
KRT23 keratin 23, type I
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MCAM melanoma cell adhesion molecule
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYBPC1 myosin binding protein C, slow type
PEG10 paternally expressed 10
PEG3 paternally expressed 3
RCAN1 regulator of calcineurin 1
RDX radixin
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SPDEF SAM pointed domain containing ETS transcription factor
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNNT1 troponin T type 1 (skeletal, slow)
TRPS1 trichorhinophalangeal syndrome I
TUBA1A tubulin, alpha 1a
WIF1 WNT inhibitory factor 1