BRD-K51290057_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

83 genes differentially expressed following the BRD-K51290057_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABHD4 abhydrolase domain containing 4
ACSL3 acyl-CoA synthetase long-chain family member 3
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
C1QB complement component 1, q subcomponent, B chain
CAPN6 calpain 6
CD163 CD163 molecule
CLU clusterin
COL4A5 collagen, type IV, alpha 5
CYBA cytochrome b-245, alpha polypeptide
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP3 dual specificity phosphatase 3
EMX2 empty spiracles homeobox 2
FXYD3 FXYD domain containing ion transport regulator 3
GCLM glutamate-cysteine ligase, modifier subunit
GPX2 glutathione peroxidase 2
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
LCN2 lipocalin 2
LMO4 LIM domain only 4
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFSD10 major facilitator superfamily domain containing 10
MLF1 myeloid leukemia factor 1
MNAT1 MNAT CDK-activating kinase assembly factor 1
NEU1 sialidase 1 (lysosomal sialidase)
NQO1 NAD(P)H dehydrogenase, quinone 1
NRCAM neuronal cell adhesion molecule
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PIR pirin (iron-binding nuclear protein)
S100A11 S100 calcium binding protein A11
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO2B1 solute carrier organic anion transporter family, member 2B1
SLPI secretory leukocyte peptidase inhibitor
SRGN serglycin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TXNRD1 thioredoxin reductase 1

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ALDOB aldolase B, fructose-bisphosphate
AREG amphiregulin
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CCND1 cyclin D1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CST6 cystatin E/M
CXADR coxsackie virus and adenovirus receptor
EREG epiregulin
FHL1 four and a half LIM domains 1
FSTL1 follistatin-like 1
GAL galanin/GMAP prepropeptide
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GJA1 gap junction protein, alpha 1, 43kDa
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
MX1 MX dynamin-like GTPase 1
PPL periplakin
PRPF4 pre-mRNA processing factor 4
RGS5 regulator of G-protein signaling 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SOX11 SRY (sex determining region Y)-box 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TCF4 transcription factor 4
TMSB15A thymosin beta 15a