BRD-K51189903_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

58 genes differentially expressed following the BRD-K51189903_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
C10ORF10 chromosome 10 open reading frame 10
CBS cystathionine-beta-synthase
CD44 CD44 molecule (Indian blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
COL11A1 collagen, type XI, alpha 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
GADD45A growth arrest and DNA-damage-inducible, alpha
GPNMB glycoprotein (transmembrane) nmb
HIST1H2AC histone cluster 1, H2ac
HIST2H2BE histone cluster 2, H2be
IGL immunoglobulin lambda locus
LAP3 leucine aminopeptidase 3
MME membrane metallo-endopeptidase
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PLK2 polo-like kinase 2
PSAT1 phosphoserine aminotransferase 1
SARS seryl-tRNA synthetase
SFRP1 secreted frizzled-related protein 1
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SPON2 spondin 2, extracellular matrix protein
TARS threonyl-tRNA synthetase
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
VAT1 vesicle amine transport 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
BIRC5 baculoviral IAP repeat containing 5
CAV2 caveolin 2
COCH cochlin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
HAL histidine ammonia-lyase
HAT1 histone acetyltransferase 1
LPL lipoprotein lipase
MXRA7 matrix-remodelling associated 7
ODC1 ornithine decarboxylase 1
PLK1 polo-like kinase 1
RPS11 ribosomal protein S11
RPS21 ribosomal protein S21
SDC4 syndecan 4
SEPW1 selenoprotein W, 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
UBE2C ubiquitin-conjugating enzyme E2C
UGCG UDP-glucose ceramide glucosyltransferase