BRD-K51189903_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-K51189903_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMDEC1 ADAM-like, decysin 1
AIM1 absent in melanoma 1
ALOX15B arachidonate 15-lipoxygenase, type B
ANKRD12 ankyrin repeat domain 12
APOC1 apolipoprotein C-I
AQP9 aquaporin 9
CCL5 chemokine (C-C motif) ligand 5
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CPM carboxypeptidase M
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
DSP desmoplakin
EDNRB endothelin receptor type B
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
GNLY granulysin
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOPX HOP homeobox
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
KRT5 keratin 5, type II
LGALS8 lectin, galactoside-binding, soluble, 8
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LRP4 low density lipoprotein receptor-related protein 4
MCL1 myeloid cell leukemia 1
MDFIC MyoD family inhibitor domain containing
MGP matrix Gla protein
MMP9 matrix metallopeptidase 9
MPPED2 metallophosphoesterase domain containing 2
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
NCAN neurocan
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFIB nuclear factor I/B
NMU neuromedin U
NOTCH2 notch 2
NT5E 5'-nucleotidase, ecto (CD73)
NTS neurotensin
PHLDA1 pleckstrin homology-like domain, family A, member 1
PI3 peptidase inhibitor 3, skin-derived
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PRF1 perforin 1 (pore forming protein)
QPCT glutaminyl-peptide cyclotransferase
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
S100A10 S100 calcium binding protein A10
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SNRPE small nuclear ribonucleoprotein polypeptide E
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TGFBR3 transforming growth factor, beta receptor III
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM100 transmembrane protein 100
TRD T cell receptor delta locus

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADD3 adducin 3 (gamma)
ALOX5 arachidonate 5-lipoxygenase
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CBR3 carbonyl reductase 3
CCNG1 cyclin G1
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
COL10A1 collagen, type X, alpha 1
CPE carboxypeptidase E
CYTH1 cytohesin 1
DICER1 dicer 1, ribonuclease type III
DLK1 delta-like 1 homolog (Drosophila)
DSE dermatan sulfate epimerase
DUSP3 dual specificity phosphatase 3
EIF5 eukaryotic translation initiation factor 5
FAM162A family with sequence similarity 162, member A
GNAS GNAS complex locus
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HSPA2 heat shock 70kDa protein 2
INSM1 insulinoma-associated 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP7 microtubule-associated protein 7
NEBL nebulette
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPTX2 neuronal pentraxin II
RGS3 regulator of G-protein signaling 3
RGS5 regulator of G-protein signaling 5
RPS4Y1 ribosomal protein S4, Y-linked 1
SCG2 secretogranin II
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TPM4 tropomyosin 4
TTC3 tetratricopeptide repeat domain 3
ZBTB38 zinc finger and BTB domain containing 38