BRD-K50387473_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

181 genes differentially expressed following the BRD-K50387473_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOT7 acyl-CoA thioesterase 7
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGTPBP1 ATP/GTP binding protein 1
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDOC aldolase C, fructose-bisphosphate
ASPN asporin
ATF3 activating transcription factor 3
CALD1 caldesmon 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCDC92 coiled-coil domain containing 92
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC37L1 cell division cycle 37-like 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHGB chromogranin B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
CPB1 carboxypeptidase B1 (tissue)
CTH cystathionine gamma-lyase
CTR9 CTR9, Paf1/RNA polymerase II complex component
CXADR coxsackie virus and adenovirus receptor
CYB5R1 cytochrome b5 reductase 1
DAPK1 death-associated protein kinase 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
ELN elastin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBXO21 F-box protein 21
FGFR3 fibroblast growth factor receptor 3
FN1 fibronectin 1
FOXN3 forkhead box N3
GADD45B growth arrest and DNA-damage-inducible, beta
GAS6 growth arrest-specific 6
GATA6 GATA binding protein 6
GLRX glutaredoxin (thioltransferase)
GSTA4 glutathione S-transferase alpha 4
H2BFS H2B histone family, member S (pseudogene)
HECA headcase homolog (Drosophila)
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-G major histocompatibility complex, class I, G
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12
IL13RA2 interleukin 13 receptor, alpha 2
INSIG1 insulin induced gene 1
ITGA6 integrin, alpha 6
KCNK3 potassium channel, two pore domain subfamily K, member 3
KDM3A lysine (K)-specific demethylase 3A
KLF11 Kruppel-like factor 11
LGMN legumain
LPIN1 lipin 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN2A1 mannosidase, alpha, class 2A, member 1
MAOB monoamine oxidase B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MFAP5 microfibrillar associated protein 5
MTSS1 metastasis suppressor 1
NDN necdin, melanoma antigen (MAGE) family member
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PEG3 paternally expressed 3
PELI1 pellino E3 ubiquitin protein ligase 1
PGBD5 piggyBac transposable element derived 5
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PRKCZ protein kinase C, zeta
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RCOR1 REST corepressor 1
RETSAT retinol saturase (all-trans-retinol 13,14-reductase)
RGS2 regulator of G-protein signaling 2
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC2 syndecan 2
SEPT10 septin 10
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SIK1 salt-inducible kinase 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STOM stomatin
STXBP1 syntaxin binding protein 1
TAGLN transgelin
TIMP3 TIMP metallopeptidase inhibitor 3
TKTL1 transketolase-like 1
TMEM2 transmembrane protein 2
TRIM36 tripartite motif containing 36
TSPAN12 tetraspanin 12
TSPAN7 tetraspanin 7
TXNIP thioredoxin interacting protein
UNC13B unc-13 homolog B (C. elegans)
VAMP3 vesicle-associated membrane protein 3
VNN1 vanin 1
WDR47 WD repeat domain 47
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
ADAM12 ADAM metallopeptidase domain 12
ADORA2B adenosine A2b receptor
AIM1 absent in melanoma 1
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ATF1 activating transcription factor 1
AURKA aurora kinase A
B3GNT1
CA12 carbonic anhydrase XII
CD58 CD58 molecule
CFD complement factor D (adipsin)
DIO2 deiodinase, iodothyronine, type II
DPYD dihydropyrimidine dehydrogenase
ECT2 epithelial cell transforming 2
EGFL6 EGF-like-domain, multiple 6
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EYA2 EYA transcriptional coactivator and phosphatase 2
FAM63A family with sequence similarity 63, member A
FHL2 four and a half LIM domains 2
FMOD fibromodulin
GABPB1 GA binding protein transcription factor, beta subunit 1
GYG2 glycogenin 2
HES1 hes family bHLH transcription factor 1
HOXB7 homeobox B7
IGF1R insulin-like growth factor 1 receptor
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INTS3 integrator complex subunit 3
JADE2 jade family PHD finger 2
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KEAP1 kelch-like ECH-associated protein 1
KIF14 kinesin family member 14
KRT15 keratin 15, type I
KRT7 keratin 7, type II
LMNB1 lamin B1
LOX lysyl oxidase
LXN latexin
MECOM MDS1 and EVI1 complex locus
MLPH melanophilin
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MPPED2 metallophosphoesterase domain containing 2
MTA1 metastasis associated 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NMI N-myc (and STAT) interactor
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PARP2 poly (ADP-ribose) polymerase 2
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PITX1 paired-like homeodomain 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRR7 proline rich 7 (synaptic)
RAB25 RAB25, member RAS oncogene family
RFX5 regulatory factor X, 5 (influences HLA class II expression)
SCGB2A2 secretoglobin, family 2A, member 2
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SFRP1 secreted frizzled-related protein 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SNRPE small nuclear ribonucleoprotein polypeptide E
SPDEF SAM pointed domain containing ETS transcription factor
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TBX2 T-box 2
TCERG1 transcription elongation regulator 1
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TLE2 transducin-like enhancer of split 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPBG trophoblast glycoprotein
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZHX2 zinc fingers and homeoboxes 2
ZNF91 zinc finger protein 91