BRD-K50387473_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

118 genes differentially expressed following the BRD-K50387473_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ALOX5 arachidonate 5-lipoxygenase
AOC3 amine oxidase, copper containing 3
BAMBI BMP and activin membrane-bound inhibitor
BTG1 B-cell translocation gene 1, anti-proliferative
C9ORF16 chromosome 9 open reading frame 16
CA2 carbonic anhydrase II
CCK cholecystokinin
CCNL1 cyclin L1
CD24 CD24 molecule
CHGB chromogranin B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
DEPTOR DEP domain containing MTOR-interacting protein
DUSP6 dual specificity phosphatase 6
EZR ezrin
FAM117A family with sequence similarity 117, member A
FBP1 fructose-1,6-bisphosphatase 1
GADD45B growth arrest and DNA-damage-inducible, beta
GRN granulin
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INSR insulin receptor
JUN jun proto-oncogene
LAMP2 lysosomal-associated membrane protein 2
MAN1A1 mannosidase, alpha, class 1A, member 1
NBPF10 neuroblastoma breakpoint family, member 10
NR4A2 nuclear receptor subfamily 4, group A, member 2
PALLD palladin, cytoskeletal associated protein
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PDLIM3 PDZ and LIM domain 3
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGDS prostaglandin D2 synthase 21kDa (brain)
REG1A regenerating islet-derived 1 alpha
RGS2 regulator of G-protein signaling 2
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SERINC5 serine incorporator 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPTAN1 spectrin, alpha, non-erythrocytic 1
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TMEM47 transmembrane protein 47
TOB1 transducer of ERBB2, 1
TRIB2 tribbles pseudokinase 2
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANXA1 annexin A1
ATF1 activating transcription factor 1
C6ORF62 chromosome 6 open reading frame 62
CD44 CD44 molecule (Indian blood group)
CD59 CD59 molecule, complement regulatory protein
CTSB cathepsin B
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
DIO2 deiodinase, iodothyronine, type II
EDN1 endothelin 1
EGFR epidermal growth factor receptor
EMP1 epithelial membrane protein 1
EMP3 epithelial membrane protein 3
FAM57A family with sequence similarity 57, member A
FBN2 fibrillin 2
FOLR1 folate receptor 1 (adult)
FXYD5 FXYD domain containing ion transport regulator 5
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JADE2 jade family PHD finger 2
KRT15 keratin 15, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LOX lysyl oxidase
MECOM MDS1 and EVI1 complex locus
MET MET proto-oncogene, receptor tyrosine kinase
MFAP2 microfibrillar-associated protein 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MT1F metallothionein 1F
MTA1 metastasis associated 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NMI N-myc (and STAT) interactor
PDGFC platelet derived growth factor C
PDLIM2 PDZ and LIM domain 2 (mystique)
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PLAC8 placenta-specific 8
PLAGL1 pleiomorphic adenoma gene-like 1
PLBD1 phospholipase B domain containing 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RBMS1 RNA binding motif, single stranded interacting protein 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SLK STE20-like kinase
SMNDC1 survival motor neuron domain containing 1
SNRPE small nuclear ribonucleoprotein polypeptide E
SORBS3 sorbin and SH3 domain containing 3
STXBP2 syntaxin binding protein 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TNNC1 troponin C type 1 (slow)
TNS3 tensin 3
TSPAN4 tetraspanin 4
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
ZNF586 zinc finger protein 586
ZNF91 zinc finger protein 91