BRD-K50387473_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

71 genes differentially expressed following the BRD-K50387473_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGR2 anterior gradient 2
AK1 adenylate kinase 1
BTG2 BTG family, member 2
C1QA complement component 1, q subcomponent, A chain
CCDC85B coiled-coil domain containing 85B
CD14 CD14 molecule
CD163 CD163 molecule
CD24 CD24 molecule
CLU clusterin
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CYBB cytochrome b-245, beta polypeptide
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
FAM171A1 family with sequence similarity 171, member A1
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCN1 ficolin (collagen/fibrinogen domain containing) 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
LTBP1 latent transforming growth factor beta binding protein 1
LXN latexin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MALL mal, T-cell differentiation protein-like
MCL1 myeloid cell leukemia 1
NID2 nidogen 2 (osteonidogen)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRGN neurogranin (protein kinase C substrate, RC3)
PF4 platelet factor 4
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SESN1 sestrin 1
SIK1 salt-inducible kinase 1
TTC3 tetratricopeptide repeat domain 3

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BEX1 brain expressed, X-linked 1
CD200 CD200 molecule
CD58 CD58 molecule
CXCL14 chemokine (C-X-C motif) ligand 14
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
EGFR epidermal growth factor receptor
ENO1 enolase 1, (alpha)
FAM57A family with sequence similarity 57, member A
HIST1H4C histone cluster 1, H4c
HMG20B high mobility group 20B
HOXA10 homeobox A10
IGFBP3 insulin-like growth factor binding protein 3
LOC100505650 uncharacterized LOC100505650
MOK MOK protein kinase
N4BP2L1 NEDD4 binding protein 2-like 1
NID1 nidogen 1
NRN1 neuritin 1
P3H2 prolyl 3-hydroxylase 2
PMM2 phosphomannomutase 2
PRSS23 protease, serine, 23
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNH1 ribonuclease/angiogenin inhibitor 1
RNPS1 RNA binding protein S1, serine-rich domain
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNX10 sorting nexin 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TGFBR3 transforming growth factor, beta receptor III
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TUBB2A tubulin, beta 2A class IIa