BRD-K50234570_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

193 genes differentially expressed following the BRD-K50234570_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BTG3 BTG family, member 3
C6ORF48 chromosome 6 open reading frame 48
CD163 CD163 molecule
CEMIP cell migration inducing protein, hyaluronan binding
CENPU centromere protein U
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLIC4 chloride intracellular channel 4
COL11A1 collagen, type XI, alpha 1
CTH cystathionine gamma-lyase
CYB5R1 cytochrome b5 reductase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
ECM1 extracellular matrix protein 1
ELANE elastase, neutrophil expressed
ETV5 ets variant 5
FAM129A family with sequence similarity 129, member A
FAM69A family with sequence similarity 69, member A
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GCLM glutamate-cysteine ligase, modifier subunit
GEM GTP binding protein overexpressed in skeletal muscle
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IL1R2 interleukin 1 receptor, type II
INSIG1 insulin induced gene 1
IPO13 importin 13
JUN jun proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCTD5 potassium channel tetramerization domain containing 5
LEF1 lymphoid enhancer-binding factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MKNK1 MAP kinase interacting serine/threonine kinase 1
MME membrane metallo-endopeptidase
MPO myeloperoxidase
MSLN mesothelin
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1M metallothionein 1M
NFIL3 nuclear factor, interleukin 3 regulated
NIT1 nitrilase 1
NUPR1 nuclear protein, transcriptional regulator, 1
OSER1 oxidative stress responsive serine-rich 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCSK1 proprotein convertase subtilisin/kexin type 1
PELI1 pellino E3 ubiquitin protein ligase 1
PELO pelota homolog (Drosophila)
PLIN2 perilipin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGCC regulator of cell cycle
RND3 Rho family GTPase 3
SAP30 Sin3A-associated protein, 30kDa
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TES testin LIM domain protein
TGFBI transforming growth factor, beta-induced, 68kDa
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TSPYL5 TSPY-like 5
TUBA4A tubulin, alpha 4a
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
AGR2 anterior gradient 2
AMD1 adenosylmethionine decarboxylase 1
APLP2 amyloid beta (A4) precursor-like protein 2
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATF5 activating transcription factor 5
ATP9A ATPase, class II, type 9A
B3GNT1
BAMBI BMP and activin membrane-bound inhibitor
BMP2 bone morphogenetic protein 2
BTBD3 BTB (POZ) domain containing 3
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD47 CD47 molecule
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CST3 cystatin C
CTSG cathepsin G
CYBA cytochrome b-245, alpha polypeptide
DAPK1 death-associated protein kinase 1
DCLK1 doublecortin-like kinase 1
DEPTOR DEP domain containing MTOR-interacting protein
DHRS11 dehydrogenase/reductase (SDR family) member 11
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNB2 ephrin-B2
EMP3 epithelial membrane protein 3
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FLNB filamin B, beta
FZD7 frizzled class receptor 7
GATA3 GATA binding protein 3
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GOLGA8H golgin A8 family, member H
GOLM1 golgi membrane protein 1
GPX3 glutathione peroxidase 3
GRWD1 glutamate-rich WD repeat containing 1
GSTM3 glutathione S-transferase mu 3 (brain)
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMG20B high mobility group 20B
HOXA5 homeobox A5
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI44L interferon-induced protein 44-like
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGSF3 immunoglobulin superfamily, member 3
KLK11 kallikrein-related peptidase 11
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT7 keratin 7, type II
LAMP5 lysosomal-associated membrane protein family, member 5
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAGEA3 melanoma antigen family A3
MARCKSL1 MARCKS-like 1
MPPED2 metallophosphoesterase domain containing 2
MREG melanoregulin
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NMB neuromedin B
NNMT nicotinamide N-methyltransferase
NR2F1 nuclear receptor subfamily 2, group F, member 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
POSTN periostin, osteoblast specific factor
PRKCD protein kinase C, delta
PROM1 prominin 1
RALGDS ral guanine nucleotide dissociation stimulator
RBP1 retinol binding protein 1, cellular
RHOBTB3 Rho-related BTB domain containing 3
SACS sacsin molecular chaperone
SCAMP1 secretory carrier membrane protein 1
SCGB2A2 secretoglobin, family 2A, member 2
SELL selectin L
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
TACSTD2 tumor-associated calcium signal transducer 2
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TNIP1 TNFAIP3 interacting protein 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIM44 tripartite motif containing 44
TYRP1 tyrosinase-related protein 1
UBE2G2 ubiquitin-conjugating enzyme E2G 2
UBL3 ubiquitin-like 3
VCAN versican
VIM vimentin
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta