BRD-K50234570_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

246 genes differentially expressed following the BRD-K50234570_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
AGTR1 angiotensin II receptor, type 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
ANXA1 annexin A1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
AZIN1 antizyme inhibitor 1
BAG3 BCL2-associated athanogene 3
BCAT1 branched chain amino-acid transaminase 1, cytosolic
C6ORF62 chromosome 6 open reading frame 62
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CANX calnexin
CBS cystathionine-beta-synthase
CCNG2 cyclin G2
CD52 CD52 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLEC2B C-type lectin domain family 2, member B
CLIC4 chloride intracellular channel 4
CPB1 carboxypeptidase B1 (tissue)
CRABP1 cellular retinoic acid binding protein 1
CSRP1 cysteine and glycine-rich protein 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP2 dual specificity phosphatase 2
EFHD1 EF-hand domain family, member D1
EFS embryonal Fyn-associated substrate
EIF5 eukaryotic translation initiation factor 5
ENPEP glutamyl aminopeptidase (aminopeptidase A)
FAM129A family with sequence similarity 129, member A
FAM69A family with sequence similarity 69, member A
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLUD1 glutamate dehydrogenase 1
GMFG glia maturation factor, gamma
GPR137B G protein-coupled receptor 137B
GUSBP3 glucuronidase, beta pseudogene 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HOXD1 homeobox D1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFNGR1 interferon gamma receptor 1
IFRD1 interferon-related developmental regulator 1
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ISOC1 isochorismatase domain containing 1
ITM2A integral membrane protein 2A
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCTD5 potassium channel tetramerization domain containing 5
KIF14 kinesin family member 14
KRT6B keratin 6B, type II
LRRC8B leucine rich repeat containing 8 family, member B
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MBNL2 muscleblind-like splicing regulator 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFSD10 major facilitator superfamily domain containing 10
MKNK2 MAP kinase interacting serine/threonine kinase 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MTA1 metastasis associated 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NID1 nidogen 1
NID2 nidogen 2 (osteonidogen)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCSK1 proprotein convertase subtilisin/kexin type 1
PEG3 paternally expressed 3
PIR pirin (iron-binding nuclear protein)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POPDC3 popeye domain containing 3
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PSAT1 phosphoserine aminotransferase 1
RAD21 RAD21 homolog (S. pombe)
RB1CC1 RB1-inducible coiled-coil 1
RIOK3 RIO kinase 3
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
SST somatostatin
TDO2 tryptophan 2,3-dioxygenase
TDP2 tyrosyl-DNA phosphodiesterase 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TLR4 toll-like receptor 4
TOP1 topoisomerase (DNA) I
TPD52 tumor protein D52
TSC22D3 TSC22 domain family, member 3
UBE2G1 ubiquitin-conjugating enzyme E2G 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase

decreased expression

Symbol Name
ACSF2 acyl-CoA synthetase family member 2
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ALCAM activated leukocyte cell adhesion molecule
ANXA3 annexin A3
APOB apolipoprotein B
ARID5B AT rich interactive domain 5B (MRF1-like)
ASRGL1 asparaginase like 1
ATF5 activating transcription factor 5
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BAD BCL2-associated agonist of cell death
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCL2L1 BCL2-like 1
BIRC3 baculoviral IAP repeat containing 3
CA12 carbonic anhydrase XII
CAPG capping protein (actin filament), gelsolin-like
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCND1 cyclin D1
CDA cytidine deaminase
CELF2 CUGBP, Elav-like family member 2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHN2 chimerin 2
CLIC3 chloride intracellular channel 3
COG2 component of oligomeric golgi complex 2
COL14A1 collagen, type XIV, alpha 1
CPVL carboxypeptidase, vitellogenic-like
CRISP3 cysteine-rich secretory protein 3
CTSH cathepsin H
CXCL12 chemokine (C-X-C motif) ligand 12
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYTH1 cytohesin 1
DCT dopachrome tautomerase
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
EDN1 endothelin 1
EFNB2 ephrin-B2
EHD1 EH-domain containing 1
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
EPN2 epsin 2
ERAP2 endoplasmic reticulum aminopeptidase 2
F13A1 coagulation factor XIII, A1 polypeptide
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP6 fatty acid binding protein 6, ileal
FBLN1 fibulin 1
FHL1 four and a half LIM domains 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FUCA1 fucosidase, alpha-L- 1, tissue
FZD7 frizzled class receptor 7
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GAS6 growth arrest-specific 6
GMPR guanosine monophosphate reductase
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GOLM1 golgi membrane protein 1
GPR183 G protein-coupled receptor 183
GPX3 glutathione peroxidase 3
GREM1 gremlin 1, DAN family BMP antagonist
GSTM3 glutathione S-transferase mu 3 (brain)
H1F0 H1 histone family, member 0
H3F3B H3 histone, family 3B (H3.3B)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IQGAP2 IQ motif containing GTPase activating protein 2
KANK2 KN motif and ankyrin repeat domains 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LOXL1 lysyl oxidase-like 1
LRRN3 leucine rich repeat neuronal 3
LXN latexin
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MLANA melan-A
MOK MOK protein kinase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC2 Niemann-Pick disease, type C2
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PDLIM2 PDZ and LIM domain 2 (mystique)
PDZK1IP1 PDZK1 interacting protein 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAC8 placenta-specific 8
PLBD1 phospholipase B domain containing 1
PMEL premelanosome protein
PPIF peptidylprolyl isomerase F
PRDX2 peroxiredoxin 2
PRR7 proline rich 7 (synaptic)
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RAB25 RAB25, member RAS oncogene family
RCAN1 regulator of calcineurin 1
REEP1 receptor accessory protein 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRAGA Ras-related GTP binding A
SACS sacsin molecular chaperone
SCO2 SCO2 cytochrome c oxidase assembly protein
SELENBP1 selenium binding protein 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
TACSTD2 tumor-associated calcium signal transducer 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGM2 transglutaminase 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMC5 transmembrane channel-like 5
TMPRSS3 transmembrane protease, serine 3
TNS1 tensin 1
TOMM34 translocase of outer mitochondrial membrane 34
TSPAN1 tetraspanin 1
TSPAN8 tetraspanin 8
TTC3 tetratricopeptide repeat domain 3
TUBB4B tubulin, beta 4B class IVb
UGCG UDP-glucose ceramide glucosyltransferase
WFDC2 WAP four-disulfide core domain 2
ZBTB18 zinc finger and BTB domain containing 18
ZCCHC24 zinc finger, CCHC domain containing 24