BRD-K50204028_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

120 genes differentially expressed following the BRD-K50204028_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCND2 cyclin D2
CXADR coxsackie virus and adenovirus receptor
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DPP4 dipeptidyl-peptidase 4
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
FOSL1 FOS-like antigen 1
FZD1 frizzled class receptor 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GREM1 gremlin 1, DAN family BMP antagonist
H2AFV H2A histone family, member V
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HOXD1 homeobox D1
HSPA13 heat shock protein 70kDa family, member 13
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ITGA6 integrin, alpha 6
ITM2C integral membrane protein 2C
JAG1 jagged 1
KCNK3 potassium channel, two pore domain subfamily K, member 3
LOC100505650 uncharacterized LOC100505650
LPAR6 lysophosphatidic acid receptor 6
MATN2 matrilin 2
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MYRF myelin regulatory factor
NEFH neurofilament, heavy polypeptide
NPTX2 neuronal pentraxin II
OSBPL10 oxysterol binding protein-like 10
PCSK1 proprotein convertase subtilisin/kexin type 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIR pirin (iron-binding nuclear protein)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLIN2 perilipin 2
PLK2 polo-like kinase 2
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
RAP1GAP RAP1 GTPase activating protein
RGCC regulator of cell cycle
SAT1 spermidine/spermine N1-acetyltransferase 1
SERINC5 serine incorporator 5
SIK1 salt-inducible kinase 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SRGN serglycin
STAR steroidogenic acute regulatory protein
STX3 syntaxin 3
SUB1 SUB1 homolog (S. cerevisiae)
TCTA T-cell leukemia translocation altered
TGFBI transforming growth factor, beta-induced, 68kDa
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRIM16 tripartite motif containing 16
TRIM2 tripartite motif containing 2
TSPAN12 tetraspanin 12
TXNRD1 thioredoxin reductase 1

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACSF2 acyl-CoA synthetase family member 2
AGR2 anterior gradient 2
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
C14ORF132 chromosome 14 open reading frame 132
CAB39 calcium binding protein 39
CCND1 cyclin D1
CD59 CD59 molecule, complement regulatory protein
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
DDAH1 dimethylarginine dimethylaminohydrolase 1
DSP desmoplakin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ERBB4 erb-b2 receptor tyrosine kinase 4
EVL Enah/Vasp-like
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM63A family with sequence similarity 63, member A
GADD45B growth arrest and DNA-damage-inducible, beta
GAS1 growth arrest-specific 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GOLM1 golgi membrane protein 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP5 insulin-like growth factor binding protein 5
KRT14 keratin 14, type I
KRT23 keratin 23, type I
KRT7 keratin 7, type II
LPL lipoprotein lipase
LTBP1 latent transforming growth factor beta binding protein 1
MAGEA1 melanoma antigen family A1
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MEIS1 Meis homeobox 1
NCOA1 nuclear receptor coactivator 1
NFIB nuclear factor I/B
NPR3 natriuretic peptide receptor 3
PIP prolactin-induced protein
RBP1 retinol binding protein 1, cellular
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFTPA2 surfactant protein A2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC38A1 solute carrier family 38, member 1
SOX11 SRY (sex determining region Y)-box 11
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF3 trefoil factor 3 (intestinal)
TRBC1 T cell receptor beta constant 1
TUBA1A tubulin, alpha 1a
WIF1 WNT inhibitory factor 1
XBP1 X-box binding protein 1