BRD-K50204028_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-K50204028_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARID5B AT rich interactive domain 5B (MRF1-like)
CLDN4 claudin 4
CNN3 calponin 3, acidic
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DSG3 desmoglein 3
EFNB2 ephrin-B2
EMP1 epithelial membrane protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F3 coagulation factor III (thromboplastin, tissue factor)
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
GCLM glutamate-cysteine ligase, modifier subunit
GPM6B glycoprotein M6B
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HOPX HOP homeobox
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV1-40 immunoglobulin lambda variable 1-40
IGLV3-19 immunoglobulin lambda variable 3-19
LMO4 LIM domain only 4
LPAR1 lysophosphatidic acid receptor 1
MAP2K3 mitogen-activated protein kinase kinase 3
NKX3-1 NK3 homeobox 1
PI3 peptidase inhibitor 3, skin-derived
PXMP2 peroxisomal membrane protein 2, 22kDa
RCAN1 regulator of calcineurin 1
RHCG Rh family, C glycoprotein
S100A9 S100 calcium binding protein A9
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLAMF7 SLAM family member 7
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINK5 serine peptidase inhibitor, Kazal type 5
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK17A serine/threonine kinase 17a
STK32B serine/threonine kinase 32B
TACSTD2 tumor-associated calcium signal transducer 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TSPAN7 tetraspanin 7
TUBB6 tubulin, beta 6 class V
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGCG UDP-glucose ceramide glucosyltransferase

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AHNAK2 AHNAK nucleoprotein 2
AKAP1 A kinase (PRKA) anchor protein 1
AMIGO2 adhesion molecule with Ig-like domain 2
APOA1 apolipoprotein A-I
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BEX4 brain expressed, X-linked 4
C7 complement component 7
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEP70 centrosomal protein 70kDa
CPE carboxypeptidase E
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DENND1B DENN/MADD domain containing 1B
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FGG fibrinogen gamma chain
GAGE3 G antigen 3
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KRT19 keratin 19, type I
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAGEA3 melanoma antigen family A3
NBEA neurobeachin
NPY1R neuropeptide Y receptor Y1
PAX6 paired box 6
PBX3 pre-B-cell leukemia homeobox 3
PCP4 Purkinje cell protein 4
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDE10A phosphodiesterase 10A
PEG3 paternally expressed 3
PNMAL1 paraneoplastic Ma antigen family-like 1
POLR1C polymerase (RNA) I polypeptide C, 30kDa
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC38A1 solute carrier family 38, member 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SQSTM1 sequestosome 1
TNNT1 troponin T type 1 (skeletal, slow)
TRIM2 tripartite motif containing 2
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAMP8 vesicle-associated membrane protein 8
VGLL1 vestigial-like family member 1