BRD-K50168500_canertinib_SKBR3_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

54 genes differentially expressed following the BRD-K50168500_canertinib_SKBR3_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APLP2 amyloid beta (A4) precursor-like protein 2
BASP1 brain abundant, membrane attached signal protein 1
CES1 carboxylesterase 1
CSTA cystatin A (stefin A)
CTSB cathepsin B
EGR2 early growth response 2
EMX2 empty spiracles homeobox 2
GPNMB glycoprotein (transmembrane) nmb
GRB10 growth factor receptor-bound protein 10
LIMA1 LIM domain and actin binding 1
NRN1 neuritin 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR3 small proline-rich protein 3
TCF4 transcription factor 4
TNC tenascin C
TP63 tumor protein p63
TSPAN5 tetraspanin 5

decreased expression

Symbol Name
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
COL3A1 collagen, type III, alpha 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
EPCAM epithelial cell adhesion molecule
EPHA3 EPH receptor A3
FAS Fas cell surface death receptor
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IFI44L interferon-induced protein 44-like
LTF lactotransferrin
MLPH melanophilin
NFIB nuclear factor I/B
NID2 nidogen 2 (osteonidogen)
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
PDHX pyruvate dehydrogenase complex, component X
PEG3 paternally expressed 3
POSTN periostin, osteoblast specific factor
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PUF60 poly-U binding splicing factor 60KDa
PYCARD PYD and CARD domain containing
SCGB2A2 secretoglobin, family 2A, member 2
SFN stratifin
SOX9 SRY (sex determining region Y)-box 9
SULF1 sulfatase 1
TFF1 trefoil factor 1
TMEM97 transmembrane protein 97
VCAN versican