BRD-K50168500_canertinib_SKBR3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

168 genes differentially expressed following the BRD-K50168500_canertinib_SKBR3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APOD apolipoprotein D
BCL6 B-cell CLL/lymphoma 6
CALB1 calbindin 1, 28kDa
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
COBL cordon-bleu WH2 repeat protein
CPD carboxypeptidase D
CRIP1 cysteine-rich protein 1 (intestinal)
CRISP3 cysteine-rich secretory protein 3
DEPTOR DEP domain containing MTOR-interacting protein
DPP4 dipeptidyl-peptidase 4
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM63A family with sequence similarity 63, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FBLN1 fibulin 1
FRMD4B FERM domain containing 4B
G0S2 G0/G1 switch 2
GAA glucosidase, alpha; acid
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GRB7 growth factor receptor-bound protein 7
KDM3A lysine (K)-specific demethylase 3A
KIAA0355 KIAA0355
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
LAMA3 laminin, alpha 3
LAMC2 laminin, gamma 2
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN1C1 mannosidase, alpha, class 1C, member 1
MT1M metallothionein 1M
MUC16 mucin 16, cell surface associated
MVP major vault protein
NBPF10 neuroblastoma breakpoint family, member 10
NBR1 neighbor of BRCA1 gene 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OFD1 oral-facial-digital syndrome 1
PBX1 pre-B-cell leukemia homeobox 1
PCDH7 protocadherin 7
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PIP prolactin-induced protein
PLA2G16 phospholipase A2, group XVI
PLCL1 phospholipase C-like 1
PSAP prosaposin
RABGAP1L RAB GTPase activating protein 1-like
RTN2 reticulon 2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCYL3 SCY1-like 3 (S. cerevisiae)
SECISBP2L SECIS binding protein 2-like
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SFTPA2 surfactant protein A2
SFTPC surfactant protein C
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC25A46 solute carrier family 25, member 46
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
TACSTD2 tumor-associated calcium signal transducer 2
TFPI2 tissue factor pathway inhibitor 2
TGFBR3 transforming growth factor, beta receptor III
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
TRIM2 tripartite motif containing 2
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSC22D3 TSC22 domain family, member 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UPK1B uroplakin 1B
VAMP8 vesicle-associated membrane protein 8
VEZF1 vascular endothelial zinc finger 1
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ADGRL2 adhesion G protein-coupled receptor L2
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AHSG alpha-2-HS-glycoprotein
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AMD1 adenosylmethionine decarboxylase 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ARG2 arginase 2
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BEX1 brain expressed, X-linked 1
BIRC5 baculoviral IAP repeat containing 5
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND1 cyclin D1
CDC20 cell division cycle 20
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CEP55 centrosomal protein 55kDa
CHPT1 choline phosphotransferase 1
CKS2 CDC28 protein kinase regulatory subunit 2
CRLF1 cytokine receptor-like factor 1
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL5 chemokine (C-X-C motif) ligand 5
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCK deoxycytidine kinase
DHCR7 7-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EXOSC4 exosome component 4
FABP7 fatty acid binding protein 7, brain
FAM171A1 family with sequence similarity 171, member A1
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FRZB frizzled-related protein
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPX3 glutathione peroxidase 3
GTSE1 G-2 and S-phase expressed 1
HACD2 3-hydroxyacyl-CoA dehydratase 2
HIST1H4C histone cluster 1, H4c
HOXA5 homeobox A5
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
JAG1 jagged 1
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT6B keratin 6B, type II
LGALS4 lectin, galactoside-binding, soluble, 4
LMNB1 lamin B1
LMO4 LIM domain only 4
LYZ lysozyme
MMP3 matrix metallopeptidase 3
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NCAPG non-SMC condensin I complex, subunit G
NEK2 NIMA-related kinase 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NOP16 NOP16 nucleolar protein
NPTX2 neuronal pentraxin II
NQO1 NAD(P)H dehydrogenase, quinone 1
NRP1 neuropilin 1
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
ODC1 ornithine decarboxylase 1
PBK PDZ binding kinase
PDGFC platelet derived growth factor C
PLK1 polo-like kinase 1
PNN pinin, desmosome associated protein
PNP purine nucleoside phosphorylase
RBP1 retinol binding protein 1, cellular
RGS4 regulator of G-protein signaling 4
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
SATB1 SATB homeobox 1
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP1 secreted frizzled-related protein 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMC4 structural maintenance of chromosomes 4
SRM spermidine synthase
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TMEM97 transmembrane protein 97
TOP2A topoisomerase (DNA) II alpha 170kDa
TPSAB1 tryptase alpha/beta 1
TUBA4A tubulin, alpha 4a
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein