BRD-K50168500_canertinib_MCF10A_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

160 genes differentially expressed following the BRD-K50168500_canertinib_MCF10A_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM10 ADAM metallopeptidase domain 10
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ASS1 argininosuccinate synthase 1
BCL6 B-cell CLL/lymphoma 6
BEX1 brain expressed, X-linked 1
BST2 bone marrow stromal cell antigen 2
C1S complement component 1, s subcomponent
CA12 carbonic anhydrase XII
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CRIP1 cysteine-rich protein 1 (intestinal)
CRYAB crystallin, alpha B
CTSV cathepsin V
CXCL14 chemokine (C-X-C motif) ligand 14
CXCR4 chemokine (C-X-C motif) receptor 4
DAPK1 death-associated protein kinase 1
DUSP1 dual specificity phosphatase 1
EGFL6 EGF-like-domain, multiple 6
EMX2 empty spiracles homeobox 2
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FOXN3 forkhead box N3
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA2 heat shock 70kDa protein 2
HSPB8 heat shock 22kDa protein 8
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
KAZN kazrin, periplakin interacting protein
KRT19 keratin 19, type I
LAMP5 lysosomal-associated membrane protein family, member 5
LOX lysyl oxidase
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
METTL7A methyltransferase like 7A
MID1 midline 1
MMP11 matrix metallopeptidase 11
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PEG10 paternally expressed 10
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PNMA2 paraneoplastic Ma antigen 2
POSTN periostin, osteoblast specific factor
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSIP1 PC4 and SFRS1 interacting protein 1
RBM47 RNA binding motif protein 47
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SULF1 sulfatase 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TSC22D3 TSC22 domain family, member 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
USP9Y ubiquitin specific peptidase 9, Y-linked
VAV3 vav 3 guanine nucleotide exchange factor
VCAN versican

decreased expression

Symbol Name
ACOX2 acyl-CoA oxidase 2, branched chain
ADORA2B adenosine A2b receptor
ADRB2 adrenoceptor beta 2, surface
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
BCL2A1 BCL2-related protein A1
BHLHE40 basic helix-loop-helix family, member e40
BIK BCL2-interacting killer (apoptosis-inducing)
BMP2 bone morphogenetic protein 2
CCL20 chemokine (C-C motif) ligand 20
CCND1 cyclin D1
CDCP1 CUB domain containing protein 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLDN4 claudin 4
COL14A1 collagen, type XIV, alpha 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EFHD2 EF-hand domain family, member D2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F3 coagulation factor III (thromboplastin, tissue factor)
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GLIPR1 GLI pathogenesis-related 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRK5 G protein-coupled receptor kinase 5
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IER2 immediate early response 2
IER3 immediate early response 3
IL1B interleukin 1, beta
ITGA6 integrin, alpha 6
ITGB6 integrin, beta 6
KCTD5 potassium channel tetramerization domain containing 5
KLF10 Kruppel-like factor 10
KRT81 keratin 81, type II
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MGLL monoglyceride lipase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NELL2 NEL-like 2 (chicken)
NOP16 NOP16 nucleolar protein
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRIP1 nuclear receptor interacting protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLEK2 pleckstrin 2
RAI14 retinoic acid induced 14
RGS10 regulator of G-protein signaling 10
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCG5 secretogranin V
SH2B3 SH2B adaptor protein 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC35F2 solute carrier family 35, member F2
SLC43A3 solute carrier family 43, member 3
SMAD3 SMAD family member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRSF7 serine/arginine-rich splicing factor 7
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STX1A syntaxin 1A (brain)
TGFA transforming growth factor, alpha
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOP1 topoisomerase (DNA) I
TRIB2 tribbles pseudokinase 2
TSC22D2 TSC22 domain family, member 2
TSPAN5 tetraspanin 5