BRD-K50168500_canertinib_MCF10A_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

109 genes differentially expressed following the BRD-K50168500_canertinib_MCF10A_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AQP1 aquaporin 1 (Colton blood group)
BASP1 brain abundant, membrane attached signal protein 1
BICC1 BicC family RNA binding protein 1
C14ORF132 chromosome 14 open reading frame 132
CA12 carbonic anhydrase XII
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHN1 chimerin 1
CLU clusterin
CNPY3 canopy FGF signaling regulator 3
CSRP2 cysteine and glycine-rich protein 2
DAPK1 death-associated protein kinase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHD1 EF-hand domain family, member D1
FBLN1 fibulin 1
FGB fibrinogen beta chain
FGFR3 fibroblast growth factor receptor 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GJA1 gap junction protein, alpha 1, 43kDa
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
HSPB8 heat shock 22kDa protein 8
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFI30 interferon, gamma-inducible protein 30
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITM2A integral membrane protein 2A
LMO2 LIM domain only 2 (rhombotin-like 1)
LOX lysyl oxidase
METTL7A methyltransferase like 7A
MFAP3L microfibrillar-associated protein 3-like
MN1 meningioma (disrupted in balanced translocation) 1
NUPR1 nuclear protein, transcriptional regulator, 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PRODH proline dehydrogenase (oxidase) 1
PROM1 prominin 1
PSPH phosphoserine phosphatase
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RGS2 regulator of G-protein signaling 2
SDC2 syndecan 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SRGN serglycin
TCF4 transcription factor 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
TXNIP thioredoxin interacting protein
VAV3 vav 3 guanine nucleotide exchange factor
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADRB2 adrenoceptor beta 2, surface
ANXA3 annexin A3
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL20 chemokine (C-C motif) ligand 20
CCND1 cyclin D1
CHD7 chromodomain helicase DNA binding protein 7
CLDN4 claudin 4
CXCL8 chemokine (C-X-C motif) ligand 8
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
EREG epiregulin
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
HBEGF heparin-binding EGF-like growth factor
HMGA2 high mobility group AT-hook 2
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IGL immunoglobulin lambda locus
IKZF1 IKAROS family zinc finger 1 (Ikaros)
JAG1 jagged 1
JUNB jun B proto-oncogene
LDLR low density lipoprotein receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIF leukemia inhibitory factor
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MYC v-myc avian myelocytomatosis viral oncogene homolog
NOP56 NOP56 ribonucleoprotein
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
POSTN periostin, osteoblast specific factor
PTX3 pentraxin 3, long
RPIA ribose 5-phosphate isomerase A
SDC4 syndecan 4
SMTN smoothelin
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOX9 SRY (sex determining region Y)-box 9
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPRY2 sprouty homolog 2 (Drosophila)
STX1A syntaxin 1A (brain)
TARBP1 TAR (HIV-1) RNA binding protein 1
TICAM1 toll-like receptor adaptor molecule 1
TM4SF1 transmembrane 4 L six family member 1