BRD-K50168500_canertinib_MCF10A_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

350 genes differentially expressed following the BRD-K50168500_canertinib_MCF10A_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
AHNAK AHNAK nucleoprotein
AHNAK2 AHNAK nucleoprotein 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA4 annexin A4
APOL1 apolipoprotein L, 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BCL6 B-cell CLL/lymphoma 6
BLVRB biliverdin reductase B
BST2 bone marrow stromal cell antigen 2
BTG1 B-cell translocation gene 1, anti-proliferative
C1R complement component 1, r subcomponent
C3 complement component 3
C9ORF3 chromosome 9 open reading frame 3
CAMLG calcium modulating ligand
CAPN1 calpain 1, (mu/I) large subunit
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CDR2L cerebellar degeneration-related protein 2-like
CFB complement factor B
CFD complement factor D (adipsin)
CLDN7 claudin 7
CLIC5 chloride intracellular channel 5
CLU clusterin
COL4A5 collagen, type IV, alpha 5
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CP ceruloplasmin (ferroxidase)
CRABP2 cellular retinoic acid binding protein 2
CRIP1 cysteine-rich protein 1 (intestinal)
CRYAB crystallin, alpha B
CSTA cystatin A (stefin A)
CTSD cathepsin D
DCN decorin
DDR1 discoidin domain receptor tyrosine kinase 1
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DEFB1 defensin, beta 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSP desmoplakin
EFNA1 ephrin-A1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
FAM46A family with sequence similarity 46, member A
FBLN1 fibulin 1
FBLN2 fibulin 2
FOXO4 forkhead box O4
FXYD3 FXYD domain containing ion transport regulator 3
GAA glucosidase, alpha; acid
GABARAPL1 GABA(A) receptor-associated protein like 1
GAS1 growth arrest-specific 1
GLUL glutamate-ammonia ligase
GM2A GM2 ganglioside activator
GPNMB glycoprotein (transmembrane) nmb
GRN granulin
GSN gelsolin
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST3H2A histone cluster 3, H2a
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDUA iduronidase, alpha-L-
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IL1B interleukin 1, beta
ISG15 ISG15 ubiquitin-like modifier
ITGB4 integrin, beta 4
JAG1 jagged 1
JAM2 junctional adhesion molecule 2
JUP junction plakoglobin
KRT13 keratin 13, type I
KRT19 keratin 19, type I
KRT23 keratin 23, type I
KRT4 keratin 4, type II
KRT6A keratin 6A, type II
KYNU kynureninase
LAMP2 lysosomal-associated membrane protein 2
LCN2 lipocalin 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LXN latexin
MEIS1 Meis homeobox 1
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MUC1 mucin 1, cell surface associated
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
NCF2 neutrophil cytosolic factor 2
NCK1 NCK adaptor protein 1
NDRG1 N-myc downstream regulated 1
NFE2L1 nuclear factor, erythroid 2-like 1
NOTCH1 notch 1
NRIP1 nuclear receptor interacting protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
OPLAH 5-oxoprolinase (ATP-hydrolysing)
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
OSR2 odd-skipped related transciption factor 2
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFD platelet derived growth factor D
PDZK1IP1 PDZK1 interacting protein 1
PEG3 paternally expressed 3
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PINK1 PTEN induced putative kinase 1
PNRC1 proline-rich nuclear receptor coactivator 1
PPL periplakin
PSAP prosaposin
PTGIS prostaglandin I2 (prostacyclin) synthase
PTN pleiotrophin
PYCARD PYD and CARD domain containing
RAB40B RAB40B, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
S100A14 S100 calcium binding protein A14
S100A4 S100 calcium binding protein A4
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3YL1 SH3 and SYLF domain containing 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC46A3 solute carrier family 46, member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLPI secretory leukocyte peptidase inhibitor
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SOD2 superoxide dismutase 2, mitochondrial
SPATA20 spermatogenesis associated 20
SPINT1 serine peptidase inhibitor, Kunitz type 1
STK38L serine/threonine kinase 38 like
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYNE2 spectrin repeat containing, nuclear envelope 2
TCEAL4 transcription elongation factor A (SII)-like 4
TGFBR3 transforming growth factor, beta receptor III
TM7SF2 transmembrane 7 superfamily member 2
TMEM45A transmembrane protein 45A
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TNXB tenascin XB
TP53I3 tumor protein p53 inducible protein 3
TRIM22 tripartite motif containing 22
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VAV3 vav 3 guanine nucleotide exchange factor
VTCN1 V-set domain containing T cell activation inhibitor 1
WBP1L WW domain binding protein 1-like
WFDC2 WAP four-disulfide core domain 2
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA3 annexin A3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CCND1 cyclin D1
CCNF cyclin F
CD44 CD44 molecule (Indian blood group)
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPM centromere protein M
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CIT citron rho-interacting serine/threonine kinase
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
COTL1 coactosin-like F-actin binding protein 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CYR61 cysteine-rich, angiogenic inducer, 61
CYTL1 cytokine-like 1
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DDAH1 dimethylarginine dimethylaminohydrolase 1
DEPDC1 DEP domain containing 1
DHFR dihydrofolate reductase
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ECT2 epithelial cell transforming 2
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ETV1 ets variant 1
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM64A family with sequence similarity 64, member A
FANCG Fanconi anemia, complementation group G
FANCI Fanconi anemia, complementation group I
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
FXYD5 FXYD domain containing ion transport regulator 5
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GAL galanin/GMAP prepropeptide
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGA2 high mobility group AT-hook 2
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IGFBP4 insulin-like growth factor binding protein 4
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
LAMP5 lysosomal-associated membrane protein family, member 5
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MALL mal, T-cell differentiation protein-like
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MLPH melanophilin
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAV3 neuron navigator 3
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NPY neuropeptide Y
NRG1 neuregulin 1
NRGN neurogranin (protein kinase C substrate, RC3)
NT5E 5'-nucleotidase, ecto (CD73)
NUSAP1 nucleolar and spindle associated protein 1
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PDE4B phosphodiesterase 4B, cAMP-specific
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RAD51AP1 RAD51 associated protein 1
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RFWD3 ring finger and WD repeat domain 3
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHCBP1 SHC SH2-domain binding protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPAG5 sperm associated antigen 5
SPATS2L spermatogenesis associated, serine-rich 2-like
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SRM spermidine synthase
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TIPIN TIMELESS interacting protein
TMEM97 transmembrane protein 97
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TRMT5 tRNA methyltransferase 5
TSPAN4 tetraspanin 4
TTK TTK protein kinase
TUBB tubulin, beta class I
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
USP1 ubiquitin specific peptidase 1
VRK1 vaccinia related kinase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein