BRD-K50168500_canertinib_HME1_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-K50168500_canertinib_HME1_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
DLK1 delta-like 1 homolog (Drosophila)
FBLN1 fibulin 1
HOXA5 homeobox A5
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
LEF1 lymphoid enhancer-binding factor 1
NUPR1 nuclear protein, transcriptional regulator, 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFC platelet derived growth factor C
PLIN2 perilipin 2
PLS3 plastin 3
PSIP1 PC4 and SFRS1 interacting protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
TSC22D3 TSC22 domain family, member 3
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKAP12 A kinase (PRKA) anchor protein 12
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL20 chemokine (C-C motif) ligand 20
CCND1 cyclin D1
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK6 cyclin-dependent kinase 6
CDV3 CDV3 homolog (mouse)
CHIC2 cysteine-rich hydrophobic domain 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DICER1 dicer 1, ribonuclease type III
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FOSL1 FOS-like antigen 1
FZD5 frizzled class receptor 5
GPRC5A G protein-coupled receptor, class C, group 5, member A
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMGA2 high mobility group AT-hook 2
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IL1B interleukin 1, beta
IL6 interleukin 6
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIF leukemia inhibitory factor
LPXN leupaxin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MCL1 myeloid cell leukemia 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NRIP1 nuclear receptor interacting protein 1
OLFM4 olfactomedin 4
PAN2 PAN2 poly(A) specific ribonuclease subunit
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLS1 plastin 1
PRKCD protein kinase C, delta
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
SATB2 SATB homeobox 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SNAP25 synaptosomal-associated protein, 25kDa
SOX9 SRY (sex determining region Y)-box 9
SPRY4 sprouty homolog 4 (Drosophila)
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
TFF1 trefoil factor 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIB2 tribbles pseudokinase 2