BRD-K50168500_canertinib_HME1_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

170 genes differentially expressed following the BRD-K50168500_canertinib_HME1_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AQP3 aquaporin 3 (Gill blood group)
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
BPHL biphenyl hydrolase-like (serine hydrolase)
BST2 bone marrow stromal cell antigen 2
C10ORF10 chromosome 10 open reading frame 10
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CD14 CD14 molecule
CD24 CD24 molecule
CFB complement factor B
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CREG1 cellular repressor of E1A-stimulated genes 1
CRIP1 cysteine-rich protein 1 (intestinal)
CRYAB crystallin, alpha B
CTSD cathepsin D
CUTA cutA divalent cation tolerance homolog (E. coli)
CXCL14 chemokine (C-X-C motif) ligand 14
DCN decorin
EDN3 endothelin 3
EFNA1 ephrin-A1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FBXO11 F-box protein 11
GAA glucosidase, alpha; acid
GM2A GM2 ganglioside activator
GPATCH8 G patch domain containing 8
GPER1 G protein-coupled estrogen receptor 1
GPNMB glycoprotein (transmembrane) nmb
GRN granulin
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFITM1 interferon induced transmembrane protein 1
ISG15 ISG15 ubiquitin-like modifier
JUP junction plakoglobin
KAZN kazrin, periplakin interacting protein
KRT15 keratin 15, type I
LAMP2 lysosomal-associated membrane protein 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LITAF lipopolysaccharide-induced TNF factor
LY6E lymphocyte antigen 6 complex, locus E
MATN2 matrilin 2
MFGE8 milk fat globule-EGF factor 8 protein
MGP matrix Gla protein
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEU1 sialidase 1 (lysosomal sialidase)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
OLFML2A olfactomedin-like 2A
PALLD palladin, cytoskeletal associated protein
PDGFD platelet derived growth factor D
PDLIM1 PDZ and LIM domain 1
PDZK1IP1 PDZK1 interacting protein 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PLA2G16 phospholipase A2, group XVI
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLK2 polo-like kinase 2
PRAME preferentially expressed antigen in melanoma
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RND3 Rho family GTPase 3
S100A8 S100 calcium binding protein A8
SCGB2A2 secretoglobin, family 2A, member 2
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLPI secretory leukocyte peptidase inhibitor
SQSTM1 sequestosome 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TAGLN transgelin
TAPBP TAP binding protein (tapasin)
TMEM45A transmembrane protein 45A
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TPD52 tumor protein D52
TPM1 tropomyosin 1 (alpha)
TRIM16 tripartite motif containing 16
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
VAT1 vesicle amine transport 1
VAV3 vav 3 guanine nucleotide exchange factor
WDR61 WD repeat domain 61
XIST X inactive specific transcript (non-protein coding)
ZIC1 Zic family member 1

decreased expression

Symbol Name
ALB albumin
ALCAM activated leukocyte cell adhesion molecule
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANPEP alanyl (membrane) aminopeptidase
ANXA3 annexin A3
APOD apolipoprotein D
AREG amphiregulin
BCL2A1 BCL2-related protein A1
BMP2 bone morphogenetic protein 2
CDC42 cell division cycle 42
CEP170 centrosomal protein 170kDa
CKAP4 cytoskeleton-associated protein 4
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSC cathepsin C
CXCL5 chemokine (C-X-C motif) ligand 5
DOCK4 dedicator of cytokinesis 4
DUSP2 dual specificity phosphatase 2
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR3 early growth response 3
EPCAM epithelial cell adhesion molecule
EREG epiregulin
ETV1 ets variant 1
FERMT1 fermitin family member 1
G0S2 G0/G1 switch 2
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GOLM1 golgi membrane protein 1
GPR183 G protein-coupled receptor 183
HMGA2 high mobility group AT-hook 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IER3 immediate early response 3
IL1B interleukin 1, beta
INHBA inhibin, beta A
LAMB3 laminin, beta 3
LMO3 LIM domain only 3 (rhombotin-like 2)
LPXN leupaxin
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MMP1 matrix metallopeptidase 1
MYBPC1 myosin binding protein C, slow type
MYO10 myosin X
NCF2 neutrophil cytosolic factor 2
NGRN neugrin, neurite outgrowth associated
NRGN neurogranin (protein kinase C substrate, RC3)
NT5E 5'-nucleotidase, ecto (CD73)
ODC1 ornithine decarboxylase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLEK pleckstrin
PLEK2 pleckstrin 2
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRR15L proline rich 15-like
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAD51C RAD51 paralog C
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RTN1 reticulon 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SIRT3 sirtuin 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
TESC tescalcin
TFPI2 tissue factor pathway inhibitor 2
THAP11 THAP domain containing 11
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
VEGFC vascular endothelial growth factor C