BRD-K50168500_canertinib_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

95 genes differentially expressed following the BRD-K50168500_canertinib_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG2 adhesion G protein-coupled receptor G2
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
COL3A1 collagen, type III, alpha 1
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DACH1 dachshund family transcription factor 1
EIF5A eukaryotic translation initiation factor 5A
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FGFR1 fibroblast growth factor receptor 1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GPM6B glycoprotein M6B
GRB10 growth factor receptor-bound protein 10
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
ITM2A integral membrane protein 2A
KRT5 keratin 5, type II
LSM1 LSM1, U6 small nuclear RNA associated
MECOM MDS1 and EVI1 complex locus
MERTK MER proto-oncogene, tyrosine kinase
MMP10 matrix metallopeptidase 10
MNAT1 MNAT CDK-activating kinase assembly factor 1
MUC16 mucin 16, cell surface associated
MXRA7 matrix-remodelling associated 7
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PODXL podocalyxin-like
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PTGDS prostaglandin D2 synthase 21kDa (brain)
RGS1 regulator of G-protein signaling 1
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
S100A8 S100 calcium binding protein A8
SCGB2A1 secretoglobin, family 2A, member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIX1 SIX homeobox 1
SLC38A6 solute carrier family 38, member 6
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM30B transmembrane protein 30B
TMEM47 transmembrane protein 47

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
BTG1 B-cell translocation gene 1, anti-proliferative
C1R complement component 1, r subcomponent
CD44 CD44 molecule (Indian blood group)
CD52 CD52 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
DUSP1 dual specificity phosphatase 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
F13A1 coagulation factor XIII, A1 polypeptide
FBXO21 F-box protein 21
FHL1 four and a half LIM domains 1
GAL galanin/GMAP prepropeptide
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GOLGA8A golgin A8 family, member A
GSTM3 glutathione S-transferase mu 3 (brain)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
LEF1 lymphoid enhancer-binding factor 1
LGALS4 lectin, galactoside-binding, soluble, 4
MAP7 microtubule-associated protein 7
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NMU neuromedin U
PBX3 pre-B-cell leukemia homeobox 3
PDLIM5 PDZ and LIM domain 5
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PPARG peroxisome proliferator-activated receptor gamma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS3 protease, serine, 3
RAB31 RAB31, member RAS oncogene family
RHOBTB3 Rho-related BTB domain containing 3
RUFY3 RUN and FYVE domain containing 3
SFRP4 secreted frizzled-related protein 4
TLE4 transducin-like enhancer of split 4
TMX4 thioredoxin-related transmembrane protein 4
TNC tenascin C
TUFT1 tuftelin 1
ZNF331 zinc finger protein 331