BRD-K50168500_canertinib_HCC515_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

102 genes differentially expressed following the BRD-K50168500_canertinib_HCC515_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADIRF adipogenesis regulatory factor
ARMCX3 armadillo repeat containing, X-linked 3
ASS1 argininosuccinate synthase 1
BLNK B-cell linker
BLVRB biliverdin reductase B
C1RL complement component 1, r subcomponent-like
C3 complement component 3
CA2 carbonic anhydrase II
CAPN1 calpain 1, (mu/I) large subunit
CAST calpastatin
CAT catalase
CCNB2 cyclin B2
CD44 CD44 molecule (Indian blood group)
CFB complement factor B
COL11A1 collagen, type XI, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CRABP2 cellular retinoic acid binding protein 2
CXADR coxsackie virus and adenovirus receptor
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DEFB1 defensin, beta 1
DHCR24 24-dehydrocholesterol reductase
EMP2 epithelial membrane protein 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM63A family with sequence similarity 63, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FOXC1 forkhead box C1
FTH1 ferritin, heavy polypeptide 1
GAA glucosidase, alpha; acid
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GPER1 G protein-coupled estrogen receptor 1
HIST1H2AC histone cluster 1, H2ac
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
KRT14 keratin 14, type I
LAMP2 lysosomal-associated membrane protein 2
LCN2 lipocalin 2
LGALS3 lectin, galactoside-binding, soluble, 3
LITAF lipopolysaccharide-induced TNF factor
MAN1A1 mannosidase, alpha, class 1A, member 1
METTL7A methyltransferase like 7A
MSMB microseminoprotein, beta-
MSMO1 methylsterol monooxygenase 1
MT1E metallothionein 1E
MUC1 mucin 1, cell surface associated
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NUPR1 nuclear protein, transcriptional regulator, 1
NXN nucleoredoxin
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PRSS23 protease, serine, 23
PTN pleiotrophin
RBM47 RNA binding motif protein 47
RNASET2 ribonuclease T2
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELENBP1 selenium binding protein 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SYBU syntabulin (syntaxin-interacting)
TACSTD2 tumor-associated calcium signal transducer 2
TIMP3 TIMP metallopeptidase inhibitor 3
TPST2 tyrosylprotein sulfotransferase 2
TRIM22 tripartite motif containing 22
TTC39A tetratricopeptide repeat domain 39A
UGDH UDP-glucose 6-dehydrogenase
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
AMIGO2 adhesion molecule with Ig-like domain 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND1 cyclin D1
CXCR4 chemokine (C-X-C motif) receptor 4
DPYSL2 dihydropyrimidinase-like 2
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FXYD5 FXYD domain containing ion transport regulator 5
GRK5 G protein-coupled receptor kinase 5
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
MGLL monoglyceride lipase
PLAC8 placenta-specific 8
PMP22 peripheral myelin protein 22
PNMA2 paraneoplastic Ma antigen 2
SIK1 salt-inducible kinase 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TFF3 trefoil factor 3 (intestinal)
TGFA transforming growth factor, alpha
TGM2 transglutaminase 2
TSPAN8 tetraspanin 8
TUBA4A tubulin, alpha 4a
TUBB4B tubulin, beta 4B class IVb