BRD-K50168500_canertinib_BT20_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

139 genes differentially expressed following the BRD-K50168500_canertinib_BT20_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADD3 adducin 3 (gamma)
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKAP7 A kinase (PRKA) anchor protein 7
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
APOLD1 apolipoprotein L domain containing 1
AZU1 azurocidin 1
BCL6 B-cell CLL/lymphoma 6
BEX1 brain expressed, X-linked 1
BHLHE41 basic helix-loop-helix family, member e41
C3 complement component 3
C9ORF16 chromosome 9 open reading frame 16
CBR3 carbonyl reductase 3
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC11A C-type lectin domain family 11, member A
CSTA cystatin A (stefin A)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DACH1 dachshund family transcription factor 1
DEFB1 defensin, beta 1
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM129A family with sequence similarity 129, member A
FGFR3 fibroblast growth factor receptor 3
FRY furry homolog (Drosophila)
GABARAPL1 GABA(A) receptor-associated protein like 1
GLUL glutamate-ammonia ligase
GOLGA8H golgin A8 family, member H
GPX2 glutathione peroxidase 2
GSTA4 glutathione S-transferase alpha 4
HOPX HOP homeobox
HTRA1 HtrA serine peptidase 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
KRT4 keratin 4, type II
LCN2 lipocalin 2
MAOA monoamine oxidase A
MDK midkine (neurite growth-promoting factor 2)
METTL7A methyltransferase like 7A
MUC1 mucin 1, cell surface associated
MXRA5 matrix-remodelling associated 5
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1H2 nuclear receptor subfamily 1, group H, member 2
PDZD2 PDZ domain containing 2
PDZK1IP1 PDZK1 interacting protein 1
PGD phosphogluconate dehydrogenase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKD1 protein kinase D1
PTN pleiotrophin
RAB31 RAB31, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RGS5 regulator of G-protein signaling 5
RHOBTB1 Rho-related BTB domain containing 1
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCAND1 SCAN domain containing 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SCRG1 stimulator of chondrogenesis 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPRR3 small proline-rich protein 3
SQSTM1 sequestosome 1
TF transferrin
TRPS1 trichorhinophalangeal syndrome I
TSC22D3 TSC22 domain family, member 3
TST thiosulfate sulfurtransferase (rhodanese)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAV3 vav 3 guanine nucleotide exchange factor
VCAN versican
VSNL1 visinin-like 1
XYLT1 xylosyltransferase I
ZNF189 zinc finger protein 189
ZNF83 zinc finger protein 83

decreased expression

Symbol Name
ADM adrenomedullin
AKAP12 A kinase (PRKA) anchor protein 12
ARHGAP29 Rho GTPase activating protein 29
AXL AXL receptor tyrosine kinase
BACE2 beta-site APP-cleaving enzyme 2
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCND1 cyclin D1
CD44 CD44 molecule (Indian blood group)
CDK4 cyclin-dependent kinase 4
CLTB clathrin, light chain B
CNN3 calponin 3, acidic
COL4A2 collagen, type IV, alpha 2
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CYR61 cysteine-rich, angiogenic inducer, 61
DCLK1 doublecortin-like kinase 1
DPYSL2 dihydropyrimidinase-like 2
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EGFR epidermal growth factor receptor
EIF5A eukaryotic translation initiation factor 5A
EVL Enah/Vasp-like
FAM57A family with sequence similarity 57, member A
FHL2 four and a half LIM domains 2
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPRC5A G protein-coupled receptor, class C, group 5, member A
IER3 immediate early response 3
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
L1CAM L1 cell adhesion molecule
MT1G metallothionein 1G
MYOF myoferlin
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PSPH phosphoserine phosphatase
PTRF polymerase I and transcript release factor
SDC2 syndecan 2
SPTBN1 spectrin, beta, non-erythrocytic 1
TFF3 trefoil factor 3 (intestinal)
TGFBI transforming growth factor, beta-induced, 68kDa
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPM1 tropomyosin 1 (alpha)
TSPAN6 tetraspanin 6
TUBB6 tubulin, beta 6 class V
UBE3C ubiquitin protein ligase E3C
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon