BRD-K50168500_canertinib_BT20_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-K50168500_canertinib_BT20_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADD3 adducin 3 (gamma)
AKAP7 A kinase (PRKA) anchor protein 7
ALOX5 arachidonate 5-lipoxygenase
AQP3 aquaporin 3 (Gill blood group)
ARID5B AT rich interactive domain 5B (MRF1-like)
BHLHE41 basic helix-loop-helix family, member e41
BST2 bone marrow stromal cell antigen 2
C1RL complement component 1, r subcomponent-like
C8ORF4 chromosome 8 open reading frame 4
CCNG2 cyclin G2
CCPG1 cell cycle progression 1
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFB complement factor B
CFD complement factor D (adipsin)
CLDN4 claudin 4
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL14 chemokine (C-X-C motif) ligand 14
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
EHF ets homologous factor
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F13A1 coagulation factor XIII, A1 polypeptide
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FXYD3 FXYD domain containing ion transport regulator 3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAS1 growth arrest-specific 1
GJA1 gap junction protein, alpha 1, 43kDa
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HMOX1 heme oxygenase 1
HOPX HOP homeobox
IFITM1 interferon induced transmembrane protein 1
IGKC immunoglobulin kappa constant
KRT13 keratin 13, type I
KRT19 keratin 19, type I
KRT4 keratin 4, type II
LAMP3 lysosomal-associated membrane protein 3
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LY6E lymphocyte antigen 6 complex, locus E
MB myoglobin
MDK midkine (neurite growth-promoting factor 2)
METTL7A methyltransferase like 7A
MPZL2 myelin protein zero-like 2
MX1 MX dynamin-like GTPase 1
MYO6 myosin VI
PBX1 pre-B-cell leukemia homeobox 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLBD1 phospholipase B domain containing 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POSTN periostin, osteoblast specific factor
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCB protein kinase C, beta
PRSS8 protease, serine, 8
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PYCARD PYD and CARD domain containing
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB31 RAB31, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RTN2 reticulon 2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SYBU syntabulin (syntaxin-interacting)
TMEM47 transmembrane protein 47
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNS1 tensin 1
TRIM38 tripartite motif containing 38
TRPS1 trichorhinophalangeal syndrome I
TSC22D3 TSC22 domain family, member 3
TSPAN12 tetraspanin 12
TSPAN13 tetraspanin 13
TUBA1A tubulin, alpha 1a
VCAN versican
WIPI1 WD repeat domain, phosphoinositide interacting 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC86 coiled-coil domain containing 86
CCND1 cyclin D1
CCNE2 cyclin E2
CDC42 cell division cycle 42
CLTB clathrin, light chain B
CST7 cystatin F (leukocystatin)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
EGFR epidermal growth factor receptor
EGR1 early growth response 1
ENO1 enolase 1, (alpha)
F3 coagulation factor III (thromboplastin, tissue factor)
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GDF15 growth differentiation factor 15
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IGF1R insulin-like growth factor 1 receptor
ITGB5 integrin, beta 5
JUN jun proto-oncogene
MET MET proto-oncogene, receptor tyrosine kinase
MINA MYC induced nuclear antigen
MRPS2 mitochondrial ribosomal protein S2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NT5E 5'-nucleotidase, ecto (CD73)
PAEP progestagen-associated endometrial protein
PFKP phosphofructokinase, platelet
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLS3 plastin 3
SH3BP4 SH3-domain binding protein 4
SLC43A3 solute carrier family 43, member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SORD sorbitol dehydrogenase
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
TGFBI transforming growth factor, beta-induced, 68kDa
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TUBB6 tubulin, beta 6 class V
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon