BRD-K50168500_canertinib_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

105 genes differentially expressed following the BRD-K50168500_canertinib_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ALAS1 5'-aminolevulinate synthase 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMDHD2 amidohydrolase domain containing 2
AMPD3 adenosine monophosphate deaminase 3
APOD apolipoprotein D
ASNS asparagine synthetase (glutamine-hydrolyzing)
BAX BCL2-associated X protein
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CTSD cathepsin D
DDIT3 DNA-damage-inducible transcript 3
ETV5 ets variant 5
FTH1 ferritin, heavy polypeptide 1
GDF15 growth differentiation factor 15
GPR137B G protein-coupled receptor 137B
HMOX1 heme oxygenase 1
HOMER1 homer scaffolding protein 1
KAZN kazrin, periplakin interacting protein
KRT23 keratin 23, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3 lectin, galactoside-binding, soluble, 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MDK midkine (neurite growth-promoting factor 2)
MTCL1 microtubule crosslinking factor 1
MVP major vault protein
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NQO1 NAD(P)H dehydrogenase, quinone 1
NRCAM neuronal cell adhesion molecule
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PLD3 phospholipase D family, member 3
PPAP2B phosphatidic acid phosphatase type 2B
PPIC peptidylprolyl isomerase C (cyclophilin C)
PTN pleiotrophin
RRAGD Ras-related GTP binding D
SCRG1 stimulator of chondrogenesis 1
SLC22A18 solute carrier family 22, member 18
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SQSTM1 sequestosome 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TPP1 tripeptidyl peptidase I
VAT1 vesicle amine transport 1
YARS tyrosyl-tRNA synthetase
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADGRF5 adhesion G protein-coupled receptor F5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AREG amphiregulin
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATAD2 ATPase family, AAA domain containing 2
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CD200 CD200 molecule
CD24 CD24 molecule
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
DUT deoxyuridine triphosphatase
EAPP E2F-associated phosphoprotein
EMP1 epithelial membrane protein 1
F13A1 coagulation factor XIII, A1 polypeptide
FASN fatty acid synthase
FHL1 four and a half LIM domains 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNAS GNAS complex locus
GPER1 G protein-coupled estrogen receptor 1
HMGB2 high mobility group box 2
HSPA1A heat shock 70kDa protein 1A
IFITM3 interferon induced transmembrane protein 3
IGFBP7 insulin-like growth factor binding protein 7
JCHAIN joining chain of multimeric IgA and IgM
KIF20A kinesin family member 20A
L1CAM L1 cell adhesion molecule
LOXL2 lysyl oxidase-like 2
MATN2 matrilin 2
MCM5 minichromosome maintenance complex component 5
MOK MOK protein kinase
NID1 nidogen 1
NMU neuromedin U
NR2F2 nuclear receptor subfamily 2, group F, member 2
PAN2 PAN2 poly(A) specific ribonuclease subunit
POSTN periostin, osteoblast specific factor
RGS5 regulator of G-protein signaling 5
SDC2 syndecan 2
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SMC4 structural maintenance of chromosomes 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SQRDL sulfide quinone reductase-like (yeast)
TCF4 transcription factor 4
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMSB15A thymosin beta 15a
TNS3 tensin 3
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated